2. Immunology/Inflammation
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  4. Anti-MUC1/CD227 Antibody (C595 (NCRC48))

Anti-MUC1/CD227 Antibody (C595 (NCRC48)) 

目录号: HY-P990831 纯度: 95.00%
COA 技术支持

Anti-MUC1/CD227 Antibody (C595 (NCRC48)) 是一种小鼠 IgG3 κ 嵌合抗体抑制剂，靶向人 MUC1/CD227。Anti-MUC1/CD227 Antibody (C595 (NCRC48)) 可特异性识别并结合肿瘤细胞表面过度表达且异常糖基化的 MUC1 蛋白，从而精准杀伤癌细胞。Anti-MUC1/CD227 Antibody (C595 (NCRC48)) 可用于癌症研究，如卵巢癌。

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Anti-MUC1/CD227 Antibody (C595 (NCRC48))

Anti-MUC1/CD227 Antibody (C595 (NCRC48)) Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥2000
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Anti-MUC1/CD227 Antibody (C595 (NCRC48)) 相关抗体

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MUC1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-MUC1/CD227 Antibody (C595 (NCRC48)) is a kind of mouse IgG3 κ chimeric antibody inhibitor, targeting to human MUC1/CD227. Anti-MUC1/CD227 Antibody (C595 (NCRC48)) specifically recognizes and binds to the MUC1 protein, which is overexpressed and abnormally glycosylated on the surface of tumor cells, thereby precisely killing cancer cells. Anti-MUC1/CD227 Antibody (C595 (NCRC48)) can be used for the researches of cancer, such as ovarian cancer[1].

同型

Mouse IgG3 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

MUC1/CD227
体内研究
(In Vivo)

Anti-MUC1/CD227 Antibody (C595 (NCRC48)) (5 or 15 mg/kg，腹腔注射，每周一次，共 3 周) 可抑制 OVCAR-3 人卵巢癌异种移植小鼠 (无胸腺 BALB/c 裸鼠) 的肿瘤生长和腹水生成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: OVCAR-3 EOC xenograft mice models (6-8 weeks, female, nude athymic BALB/c)[1]
Dosage: 5 or 15 mg/kg
Administration: Intraperitoneally injection, once a week for 3 weeks
Result: Produced less ascites.
Inhibited tumor growth.
Reduced CA125 levels at 15 mg/kg.
Reduced targeted lesions.
基因 ID

4582  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-MUC1/CD227 Antibody (C595 (NCRC48)) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-MUC1/CD227 Antibody (C595 (NCRC48))MucinMUC1CD227CA15-3Ovarian cancerOVCAR-3Inhibitorinhibitorinhibit

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目录号：
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