1. Immunology/Inflammation
  2. NOD-like Receptor (NLR) Interleukin Related
  3. Anti-neuroinflammation agent 1

Anti-neuroinflammation agent 1 

目录号: HY-155762
产品使用指南

Anti-neuroinflammation agent 1 是一种强效抗神经炎症剂,可调节 BV2 小胶质细胞从 M1 表型到 M2 表型的极化。

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Anti-neuroinflammation agent 1 Chemical Structure

Anti-neuroinflammation agent 1 Chemical Structure

CAS No. : 2968412-77-1

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-neuroinflammation agent 1 is a potent anti-neuroinflammation agent that regulates polarization BV2 microglia cells from M1 phenotype to M2 phenotype[1].

体外研究
(In Vitro)

Anti-neuroinflammation agent 1 (BMP 29) 在体外显示出更有效的抗神经炎症活性,并且对 BV2 小胶质细胞没有毒性。 在脂多糖(LPS)诱导的 BV2 小胶质细胞中,Anti-neuroinflammation agent 1 显着减少M1表型小胶质细胞的数量,但显着增加M2表型小胶质细胞的数量。Anti-neuroinflammation agent 1 显着减少炎症细胞因子(IL-18、IL-1β、TNF-α)的分泌,但增加 LPS 诱导的 BV2 小胶质细胞分泌抗炎细胞因子(IL-10)。此外,Anti-neuroinflammation agent 1 还可抑制 NOD 样受体 NLRP3 炎症小体的形成,并下调 LPS 诱导的 BV2 小胶质细胞中丙酮酸激酶 M2 亚型的表达[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

在小鼠中,Anti-neuroinflammation agent 1 (BMP 29) 通过降低诱导型一氧化氮合酶的表达来减轻铜宗诱导的炎症和脱髓鞘小鼠的神经炎症,但会增加 CD206 的表达[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

523.86

Formula

C22H20ClF6N3O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Anti-neuroinflammation agent 1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Anti-neuroinflammation agent 1
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HY-155762
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