2. Immunology/Inflammation
  3. CD28
  4. Anti-Rat CD28 Antibody (JJ316)

Anti-Rat CD28 Antibody (JJ316) 

目录号: HY-P990819
技术支持

Anti-Rat CD28 Antibody (JJ316) 是一种源自小鼠的激动型 IgG1 κ 型抗体，靶向大鼠 CD28。Anti-Rat CD28 Antibody (JJ316) 可诱导 T 细胞增殖。Anti-Rat CD28 Antibody (JJ316) 可用于炎症、免疫学和神经系统疾病的研究，如实验性自身免疫性脑脊髓炎 (EAE) 和移植物抗宿主病 (GvHD)。

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Anti-Rat CD28 Antibody (JJ316)

Anti-Rat CD28 Antibody (JJ316) Chemical Structure

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Anti-Rat CD28 Antibody (JJ316) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Rat CD28 Antibody (JJ316) is a mouse-derived agonistic IgG1 κ type antibody, targeting to rat CD28. Anti-Rat CD28 Antibody (JJ316) can induce T cell proliferation. Anti-Rat CD28 Antibody (JJ316) can be used for the researches of inflammation, immunology and neurological disease, such as experimental autoimmune encephalomyelitis (EAE) and graft-versus-host disease (GvHD)[1][2].

同型

Mouse IgG1 kappa
反应种属

Rat
IC50 & Target

CD28
体内研究
(In Vivo)

Anti-Rat CD28 Antibody (JJ316) (0.1 or 1 mg/rat, i.v., a single dose) 可以使来自 Lewis 大鼠的CD4+CD25+ 调节性 T 细胞抑制髓鞘碱性蛋白驱动的 T 细胞增殖[1]。
Anti-Rat CD28 Antibody (JJ316) (0.1-1 mg/rat，静脉注射，单剂量) 可诱导成年 Lewis 大鼠的调节性 T 细胞增殖[1]。
Anti-Rat CD28 Antibody (JJ316) (0.03-1 mg/rat，静脉注射，单剂量) 可减轻髓鞘少突胶质细胞糖蛋白 (MOG) 诱导的实验性自身免疫性脑脊髓炎 (EAE) 大鼠模型中 EAE 的严重程度[1]。
Anti-Rat CD28 Antibody (JJ316) (1 mg/rat，静脉注射，单剂量) 可增加 Lewis 大鼠体内 CD4+CD25+ T 细胞数量，并提高 IL-2 、IL-4、IL-10 和 Foxp3 的水平[2]。
Anti-Rat CD28 Antibody (JJ316) (1 mg/rat，静脉注射，单剂量) 可抑制脾脏移植的 Lewis 和 DA 杂交大鼠的移植物抗宿主病 (GvHD) 反应[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult Lewis rats[1]
Dosage: 0.1, 0.3 and 1 mg/rat
Administration: Intravenously injection
Result: Led to a significant increase in CD25+ cells among CD4+ cells in peripheral lymph nodes and in the spleen.
Led to a increase in CD25+ cells among CD4- cells at 1 mg/rat.
Increased transferred Treg cells further up-regulated CD25 expression.
Showed 97% of Tconv cells undergone at least one cell division at 1 mg/rat.
Showed that the vast majority of CD4+CD25+ cells, and all CD4+CD25high cells, continued to express FoxP3.
Animal Model: Myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) rat models[1]
Dosage: 0.03, 0.1, 0.3 and 1 mg/rat
Administration: Intravenously injection, at days 0 and 10
Result: Immediately ameliorated disease activity at 1 mg/rat.
Reduced the severity of EAE.
Animal Model: Spleen transferred Lewis × DA hybrid rats[2]
Dosage: 1 mg/rat
Administration: Intravenously injection
Result: Showed no enlargement was found in the PLN on the left side.
Inhibited the GvHD mortality significantly.
Showed relatively few infiltrating mononu-clear cells and almost normal tissue architecture.
基因 ID

12487  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Rat CD28 Antibody (JJ316) 相关分类

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Rat CD28 Antibody (JJ316)CD28T cellsEAEGvHDFoxp3MOGInhibitorinhibitorinhibit

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