2. Immunology/Inflammation
  3. Fc Receptor (FcR)
  4. Anti-Rat FcRn heavy chain heterodimers Antibody (1G3)

Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) 

目录号: HY-P990818 纯度: ≥95.0%
COA 技术支持

Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) 是一种抗大鼠的 FcRn heavy chain heterodimers IgG1 单克隆抗体。Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) 能有效结合 FcRn，并竞争性抑制 IgG 与 FcRn 结合。Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) 可以降低血清总 IgG 水平。Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) 可用于研究自身免疫性疾病，如实验性自身免疫性重症肌无力 (EAMG)。Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) 的同型对照为 Mouse IgG1 kappa, Isotype Control (HY-P99977)。

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Anti-Rat FcRn heavy chain heterodimers Antibody (1G3)

Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) Chemical Structure

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Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) is an anti-rat FcRn heavy chain heterodimers IgG1 monoclonal antibody. Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) can effectively bind to FcRn and competitively inhibit the binding of IgG to FcRn. Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) can reduce the total serum IgG level. Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) can be used for researches on autoimmune conditions such as experimental autoimmune myasthenia gravis (EAMG). The recommend isotype control of Anti-Rat FcRn heavy chain heterodimers Antibody (1G3): Mouse IgG1 kappa, Isotype Control (HY-P99977)[1][2].

同型

Human IgG1 kappa
推荐同型对照抗体
反应种属

Rat
IC50 & Target

FcRn heavy chain heterodimers
体内研究
(In Vivo)

Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) (1-30 mg/kg，腹腔注射，在用 AChR mAb 35 诱导疾病前 2 小时和 24 小时) 几乎完全预防了具有实验性自身免疫性重症肌无力 (EAMG) 模型的雌性 Lewis 大鼠的疾病症状[1]。
Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) (30 mg/kg，腹腔注射，每周 3 次) 显著缓解了实验性自身免疫性重症肌无力 (EAMG) 模型雌性 Lewis 大鼠的疾病症状[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: AChR mAb 35 (0.75-1 mg/kg) induced female Lewis rats (100 g)[1]
Dosage: 1, 3, 10 and 30 mg/kg
Administration: Intraperitoneal injection (i.p.), at 2 and 24 h before disease induction with AChR mAb 35
Result: Significantly reduced disease score at 30 mg/kg.
Significantly reduced serum mAb 35 level.
Maintained normal weight and grip strength, while the control group decreased.
Animal Model: AChR and CFA (HY-153808) induced female Lewis rats (6-7 weeks, 150 g)[1]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection (i.p.), 3 times a week
Result: Significantly reduced disease score.
Reduced serum total IgG and anti-AChR IgG levels, but did not affect IgM.
Had no effect on spleen and lymph node weight.
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: ≥95.0%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) 相关分类

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Rat FcRn heavy chain heterodimers Antibody (1G3)Fc Receptor (FcR)Fc ReceptorFcRnIgGEAMGInhibitorinhibitorinhibit

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Anti-Rat FcRn heavy chain heterodimers Antibody (1G3)
目录号：
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