2. Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. Apoptosis Caspase PARP
  4. Antitumor agent-72

Antitumor agent-72 是一种有效的抗癌剂。Antitumor agent-72 具有抗癌活性，并通过激活 caspase-3 和裂解 PARP 诱导细胞凋亡 (apoptosis)。Antitumor agent-72 可用于癌症研究。

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Antitumor agent-72 Chemical Structure

Antitumor agent-72 Chemical Structure

CAS No. : 2676942-92-8

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Antitumor agent-72 相关抗体

Top Publications Citing Use of Products

查看 Caspase 亚型特异性产品:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 PARP 亚型特异性产品:

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-72 (compound 6w) is a potent anticancer agent. Antitumor agent-72 has anticancer activity and induces apoptosis through activation of caspase-3 and cleavage of PARP. Antitumor agent-72 can be used for cancer research[1].

体外研究
(In Vitro)

Antitumor agent-72 (compound 6w) (0-10 µM; 72 h; BxPC3, PC3 and MCF7 cells) has anticancer activity and inhibits cell viability in a dose-dependent manner[1].
Antitumor agent-72 (compound 6w) (0-10 µM; 24 h; BxPC3 cells) induces apoptosis through activation of caspase-3 and cleavage of PARP[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-72 相关抗体:

Cell Viability Assay[1]

Cell Line: BxPC3, PC3 and MCF7 cells
Concentration: 0, 0.03, 0.1, 0.3, 1, 3 and 10 µM
Incubation Time: 72 hours
Result: Inhibited cell viability in BxPC3, PC3 and MCF7 cells with IC50 values of 0.47 µM, 2.68 µM and 1.82 µM, respectively.

Western Blot Analysis[1]

Cell Line: BxPC3 cells
Concentration: 0, 0.1, 0.3, 1, 3 and 10 µM
Incubation Time: 24 hours
Result: Increased caspase-3 activation and PARP cleavage in BxPC3 cells.
分子量

465.88

Formula

C25H20ClNO6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-72 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-722676942-92-8Antitumor agent72Antitumor agent 72ApoptosisCaspasePARPpoly ADP ribose polymeraseanticancercaspase-3apoptosisBxPC3Inhibitorinhibitorinhibit

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