1. Metabolic Enzyme/Protease
  2. Ser/Thr Protease
  3. APC-6860

APC-6860 是一种胰蛋白酶样丝氨酸蛋白酶 (trypsin-like serine proteases) 抑制剂,对于 uPA、胰蛋白酶的 ki 值为 0.21 和 0.44 μM。APC-6860 对 tPA 与 uPA 的选择性比为 80。APC-6860 对人和鼠尿激酶的 ki 值分别为 0.1 和 0.082 μM。APC-6860 可用于癌症研究。

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APC-6860 Chemical Structure

APC-6860 Chemical Structure

CAS No. : 154628-42-9

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

APC-6860 is a trypsin-like serine proteases inhibitor with ki values of 0.21 and 0.44 μM for uPA and trypsin, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has ki values of 0.1 and 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer[1][2].

IC50 & Target[1][2]

uPA

0.21 μM (Ki)

trypsin

0.44 μM (Ki)

tryptase

1.5 μM (Ki)

tPA

16.8 μM (Ki)

thrombin

20 μM (Ki)

factor Xa

30 μM (Ki)

human urokinases

0.1 μM (Ki)

murine urokinases

0.082 μM (Ki)

体外研究
(In Vitro)

APC-6860 (compound 2) inhibits urokinases in MiaPaCa-2 and Lewis Lung Carcinoma cells with IC50s of 1.4 and 3.1 μM, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

302.13

Formula

C9H7IN2S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
APC-6860
目录号:
HY-114015
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