2. Apoptosis Metabolic Enzyme/Protease Cytoskeleton
  3. Apoptosis Bcl-2 Family Caspase MMP Cadherin
  4. Apoptosis inducer 44

Apoptosis inducer 44 是一种凋亡 (apoptosis) 诱导剂。Apoptosis inducer 44 通过增加 Bax 和 Cyt C 的水平、降低 Bcl-2 的水平以及启动 caspase-3 的切割来引发 MDA-MB-231 细胞凋亡。Apoptosis inducer 44 通过下调 MMP-2 和 MMP-9 的表达以及上调 E-cadherin 的蛋白水平来抑制 MDA-MB-231 细胞的侵袭和迁移。Apoptosis inducer 44 可用于乳腺癌的研究。

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Apoptosis inducer 44

Apoptosis inducer 44 Chemical Structure

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Apoptosis inducer 44 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3

查看 Caspase 亚型特异性产品:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 MMP 亚型特异性产品:

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Apoptosis inducer 44 is an apoptosis inducer. Apoptosis inducer 44 triggers apoptosis in MDA-MB-231 cells by increasing the levels of Bax and Cyt C, reducing Bcl-2, and initiating caspase-3 cleavage. Apoptosis inducer 44 suppresses the invasion and migration of MDA-MB-231 cells by down-regulating MMP-2 and MMP-9 expression and up-regulating E-cadherin protein levels. Apoptosis inducer 44 can be used for the study of breast cancer[1].

IC50 & Target[1]

Caspase 3

 

Bax

 

Bcl-2

 

MMP-2

 

MMP-9

 

体外研究
(In Vitro)

Apoptosis inducer 44 (Compound 19) (72 h) 对MDA-MB-231细胞、MCF-7细胞、4T1 细胞和 Aml-12 细胞表现出细胞毒活性，IC50 值分别为4.13、8.60、39.95 和 31.60 μM[1]。
Apoptosis inducer 44 (10‑40 μM) 通过线粒体途径诱导 MDA-MB-231 细胞凋亡[1]。
Apoptosis inducer 44 (5 40 μM) 通过下调 MMP-2/MMP-9 表达和上调 E-钙粘蛋白水平来抑制 MDA-MB-231 细胞的侵袭和迁移[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 44 相关抗体:
体内研究
(In Vivo)

Apoptosis inducer 44 (Compound 19) (20 mg/kg, for 18 days) 显著抑制MDA-MB-231 细胞异种移植裸鼠体内的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

483.61

Formula

C30H36F3NO
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Apoptosis inducer 44 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 44Apoptosis inducer44Apoptosis inducer-44ApoptosisBcl-2 FamilyCaspaseMMPCadherinMatrix metalloproteinasesAnti-breast cancerMDA-MB-231 cellsMCF-7 cells4T1 cellsAml-12 cellsInhibitorinhibitorinhibit

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