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  3. Apovincaminic acid hydrochloride salt

Apovincaminic acid hydrochloride salt 

目录号: HY-133813A 纯度: >98.0%
产品使用指南

Apovincaminic acid hydrochloride salt 是 Vinpocetine (VP) 的一种具有口服活性和可透过血脑屏障的主要活性代谢产物。Apovincaminic acid hydrochloride salt 具有神经保护作用。

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Apovincaminic acid hydrochloride salt Chemical Structure

Apovincaminic acid hydrochloride salt Chemical Structure

CAS No. : 72296-47-0

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Description

Apovincaminic acid hydrochloride salt is an orally active and brain-penetrant main active metabolite of Vinpocetine (VP). Apovincaminic acid hydrochloride salt exerts a neuroprotective type of action[1][2].

In Vivo

Apovincaminic acid (10 mg/kg; i.p. twice daily for 4 days) effectively attenuates the behavioral deficits, and significantly decreases lesion size and the region of microglia activation[1].
Apovincaminic acid (10 mg/kg; p.o.) is absorbed 50% of the dose comparing with i.v. administration in rats[2].

Animal Model: Male Harlan‐Wistar rats (300-400 g) are injected NMDA[1]
Dosage: 10 mg/kg
Administration: I.p. twice daily for 4 days
Result: Attenuated the attention deficit effectively.
Prevented the learning and memory impairment in the spontaneous alternation and Morris water maze tests.
significantly reduced lesion size microglia activation.
Molecular Weight

358.86

Formula

C₂₀H₂₃ClN₂O₂

CAS No.

72296-47-0

SMILES

CC[C@@]12[C@@]3([H])C4=C(CCN3CCC2)C5=CC=CC=C5N4C(C(O)=O)=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Apovincaminic acidDrug MetabolitemetaboliteVinpocetineVPneuroprotectiveInhibitorinhibitorinhibit

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产品名称:
Apovincaminic acid hydrochloride salt
目录号:
HY-133813A
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