2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. ARGX-119

ARGX-119 是一种针对肌肉特异性激酶（MuSK）特异的一流人源化激动剂单克隆抗体。ARGX-119可用于神经肌肉疾病的研究。ARGX-119 的同型对照可参考 Human IgG1 lambda1, Isotype Control (HY-P99992)。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CAS No. : 2966023-63-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
1 mg   询价  
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

ARGX-119 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ARGX-119 is a first-in-class humanized agonist monoclonal antibody specific for muscle-specific kinase (MuSK). ARGX-119 can be used for the study of neuromuscular diseases. The isotype control for ARGX-119 can refer to Human IgG1 lambda1, Isotype Control (HY-P99992)[1].

同型

Human IgG1 lambda
推荐同型对照抗体
反应种属

Human
IC50 & Target

MuSK

体外研究
(In Vitro)

ARGX-119 与人类、非人类灵长类动物、大鼠和小鼠 MuSK 的 Frizzled 样结构域具有高亲和力结合，没有脱靶结合，适合临床开发。在 Fc 区域内，ARGX-119 含有 L234A 和 L235A 突变，可削弱潜在的免疫激活效应功能。其作用方式是激活 MuSK，而不会干扰其天然配体神经 Agrin，并以剂量​​依赖性方式聚集乙酰胆碱受体，从而稳定神经肌肉功能[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ARGX-119 相关抗体:
体内研究
(In Vivo)

在 DOK7 先天性肌无力 (CM) 小鼠模型中，ARGX-119 (20 mg/kg) 可通过剂量依赖性方式恢复神经肌肉功能并减少肌肉无力和易疲劳，从而预防早期出生后死亡并逆转成年 Dok7 CM 小鼠的疾病复发[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
基因 ID

4593  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized MUSK Protein, Human (P.pastoris, His, HY-P72273) can bind ARGX-119. The EC50 for this effect is 932.5 ng/mL.
纯度 & 产品资料
参考文献

ARGX-119 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ARGX-1192966023-63-0ARGX119ARGX 119nAChRNicotinic acetylcholine receptorsMuSK agonistInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
ARGX-119
目录号：
HY-P991066
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z