1. NF-κB Immunology/Inflammation Membrane Transporter/Ion Channel
  2. NF-κB NOD-like Receptor (NLR) Sodium Channel
  3. Articaine

Articaine  (Synonyms: Hoe-045 free base)

目录号: HY-B0516A
产品使用指南

Articaine (Hoe-045 free base) 是一种含酯基的酰胺类麻醉剂,可逆地与神经内腔内电压门控钠通道的α亚基结合,能有效缓解疼痛。Articaine 通过抑制 NF-ĸB 的激活和 NLRP3 炎症小体通路改善脂多糖 (LPS) 诱导的急性肾损伤。

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Articaine Chemical Structure

Articaine Chemical Structure

CAS No. : 23964-58-1

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  • 生物活性

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  • 参考文献

生物活性

Articaine (Hoe-045 free base) is an amide anaesthetic containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway[1][2][3].

IC50 & Target

NF-ĸB, NLRP3, sodium channel[2][3]

Clinical Trial
分子量

284.37

Formula

C13H20N2O3S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Articaine
目录号:
HY-B0516A
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