1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. ATI-2341

ATI-2341 

目录号: HY-P0172
产品使用指南

ATI-2341 是一种有效的 C-X-C 趋化因子受体 4 型 (CXCR4) 功能选择性变构激动剂,其作为偏向配体起作用,有利于 Gα1激活而不是 Gα13。ATI-2341 激活抑制性异源三聚体 G 蛋白 (Gi) 以促进 cAMP 产生的抑制并诱导钙动员。ATI-2341 是一种有效骨髓多形核中性粒细胞 (PMNs) 和造血干细胞和祖细胞 (HSPCs) 动员剂。

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Custom Peptide Synthesis

ATI-2341 Chemical Structure

ATI-2341 Chemical Structure

CAS No. : 1337878-62-2

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Description

ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs)[1][2].

IC50 & Target[1]

CXCR4

194 nM (EC50, in CCRF-CEM cells)

In Vitro

ATI-2341 induces CXCR4- and G protein-dependent signaling, receptor internalization, and chemotaxis in CXCR4-expressing cells. ATI-2341 has an EC50 value of 194 ± 16 nM and an intrinsic activity of 81 ± 4% in CCRF-CEM cells[2].

Molecular Weight

2256.82

Formula

C₁₀₄H₁₇₈N₂₆O₂₅S₂

CAS No.

1337878-62-2

Sequence

1-Oxohexadecyl-Met-Gly-Tyr-Gln-Lys-Lys-Leu-Arg-Ser-Met-Thr-Asp-Lys-Tyr-Arg-Leu

Sequence Shortening

1-Oxohexadecyl-MGYQKKLRSMTDKYRL

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

Keywords:

ATI-2341ATI2341ATI 2341CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsInhibitorinhibitorinhibit

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产品名称:
ATI-2341
目录号:
HY-P0172
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