1. GPCR/G Protein
  2. Protease Activated Receptor (PAR)
  3. Atopaxar hydrobromide

Atopaxar hydrobromide  (Synonyms: E5555 hydrobromide; ER 172594-06)

目录号: HY-18200B
产品使用指南

Atopaxar (E5555) hydrobromide 是一种高效、有口服活性的,选择性的,可逆凝血酶受体蛋白酶激活受体-1 (PAR-1) 拮抗剂。Atopaxar hydrobromide 是一种抗血小板剂,能干扰血小板信号。Atopaxar hydrobromide 可用于动脉粥样硬化血栓性疾病的研究。

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Atopaxar hydrobromide Chemical Structure

Atopaxar hydrobromide Chemical Structure

CAS No. : 474550-69-1

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规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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Atopaxar hydrobromide 的其他形式现货产品:

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Atopaxar (E5555) hydrobromide is a potent, orally active, selective and reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist. Atopaxar hydrobromide, an antiplatelet agent, interferes with platelet signaling. Atopaxar hydrobromide can be used for the research of atherothrombotic disease[1][2].

IC50 & Target

PAR-1[1]

体外研究
(In Vitro)

Atopaxar hydrobromide (0.0001-10 μM; 1h) inhibits haTRAP (high-affinity thrombin receptor activating peptide) binding to PAR-1 on human platelet membranes in a concentration-dependent manner, with an IC50 of 0.019 μM[2].
Atopaxar hydrobromide shows potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC50s of 0.064 and 0.031 μM, respectively, but has no effect on platelet aggregation induced by either ADP or collagen[2].
Atopaxar hydrobromide shows potent and selective inhibitory effects on guinea pig platelet aggregation induced by thrombin and TRAP with IC50s of 0.13 and 0.097 μM, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Atopaxar (30-100 mg/kg; p.o.) hydrobromide causes a dose-dependent prolongation of the time to occlusion of the femoral artery in photochemically-induced thrombosis (PIT) guinea pigs model[2].
Atopaxar hydrobromide does not prolong bleeding time in guinea pigs at the highest tested dosage of 1000 mg/kg[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Guinea pigs, PIT model[2]
Dosage: Oral administration
Administration: 10 mg/kg, 30 mg/kg, 100 mg/kg
Result: Prolonged the time to occlusion by 1.8-fold and 2.4-fold at 30 mg/kg and 100 mg/kg, respectively, compared with controls.
Clinical Trial
分子量

608.54

Formula

C29H39BrFN3O5

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据
  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案源自文献,仅供参考,建议您先取少量样品进行尝试。

  • 方案 一

    Atopaxar hydrobromide (E5555) is prepared in the 0.5% methylcellulose solution[2].

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Atopaxar hydrobromide 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Atopaxar hydrobromide
目录号:
HY-18200B
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