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  3. Befovacimab

Befovacimab  (Synonyms: BAY 1093884)

目录号: HY-P99465

Befovacimab (BAY 1093884) 是一种全人源单克隆 IgG2 抗体,能够结合组织因子通路抑制剂 (TFPI)。Befovacimab 可用于血友病 A/B 研究。

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Befovacimab Chemical Structure

Befovacimab Chemical Structure

CAS No. : 2156634-62-5

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Befovacimab (BAY 1093884) is a fully human monoclonal IgG2 antibody able to bind to tissue factor pathway inhibitor (TFPI). Befovacimab can be used for haemophilia A/B research[1].

体外研究
(In Vitro)

Befovacimab 通过 K1 和 K2 结构域以高亲和力 (<10 pM) 结合人 TFPI,抑制其与 FXa 和 FVIIa 的相互作用,从而恢复它们的活性[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

在猴血浆中,Befovacimab 对游离 TFPI 和稀释的凝血酶原时间 (dPT) 的 IC50 分别为 4.65 nM 和 6.19 nM[1]
Befovacimab(5 和 20 mg/kg;静脉和皮下给药)剂量依赖性降低体内雌性食蟹猴的 TFPI 浓度和凝血时间[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS 号
中文名称

贝弗西单抗

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Befovacimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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