2. Neuronal Signaling NF-κB
  3. Amyloid-β NF-κB
  4. β-Amyrin

β-Amyrin  (Synonyms: β-香树脂醇)

目录号: HY-N2922 纯度: 99.95%
COA 产品使用指南 技术支持

β-Amyrin 能够有效对抗 β-淀粉样蛋白 (Aβ) 诱导的长时程增强 (LTP) 损伤，可用于阿尔茨海默病 (AD) 研究。β-Amyrin 有抗炎作用、抗肺纤维化以及显著的抗菌能力。β-Amyrin 是一种口服有效的天然三萜类化合物。

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β-Amyrin

β-Amyrin Chemical Structure

CAS No. : 559-70-6

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Customer Review

Other Forms of β-Amyrin:

β-Amyrin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

β-Amyrin shows effectively counteract amyloid β (Aβ)-induced impairment of long-term potentiation (LTP). β-Amyrin is a promising candidate for Alzheimer's disease (AD) research. β-Amyrin exhibits anti-inflammatory effects, protective activity against pulmonary fibrosis, and notable antibacterial capabilities. β-Amyrin is an orally active natural triterpenoid compound[1][2][3][4].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
23.55 μM
Compound: 10
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 28482219]
B16 ED50
> 50 μM
Compound: 14
Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days
Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days
[PMID: 12027734]
B16 IC50
48.8 μM
Compound: 14
Growth inhibition of mouse B16 2F2 cells after 3 days
Growth inhibition of mouse B16 2F2 cells after 3 days
[PMID: 12027734]
DU-145 IC50
27.88 μM
Compound: 10
Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 28482219]
HEK293 IC50
94.4 μM
Compound: 10
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 28482219]
HeLa IC50
> 50 μM
Compound: 4
Cytotoxicity against human HeLa cells by MTT assay
Cytotoxicity against human HeLa cells by MTT assay
[PMID: 19447618]
HeLa IC50
27.94 μM
Compound: 10
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 28482219]
J774 IC50
> 234.3 μM
Compound: 2
Cytotoxicity against mouse J774 cells by alamar blue assay
Cytotoxicity against mouse J774 cells by alamar blue assay
[PMID: 17637068]
MCF7 IC50
> 50 μM
Compound: 4
Cytotoxicity against human MCF7 cells by MTT assay
Cytotoxicity against human MCF7 cells by MTT assay
[PMID: 19447618]
MCF7 IC50
35.31 μM
Compound: 10
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 28482219]
SK-MEL-1 IC50
> 50 μM
Compound: 4
Cytotoxicity against human SK-MEL-1 cells by MTT assay
Cytotoxicity against human SK-MEL-1 cells by MTT assay
[PMID: 19447618]
体外研究
(In Vitro)

β-Amyrin (1-100 μM, 0-80 min) 阻断 Aβ 诱导的小鼠海马体组织突触功能障碍[1]。
β-Amyrin (1-10 μg, 24 h 15 min) 在培养的 hPBMCs (人外周血单核细胞) 中显示抗氧化活性[2]。
β-Amyrin (5-20 μg/mL, 16-24 h) 剂量依赖性地显著抑制 LPS 诱导的 hPBMCs 中 PGE2 (HY-101952)，IL-6 分泌和 NF-κB 活化[2]。
β-Amyrin (5 μM, 2 h) 展现出抗菌作用，通过产生活性氧 ROS 促进大肠杆菌发生凋亡样死亡[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

β-Amyrin 相关抗体:

Apoptosis Analysis[4]

Cell Line: E. coli (BW 25113)
Concentration: 5 μM
Incubation Time: 2 h
Result: Decreased GSH/GSSG ratio and induced membrane depolarization and DNA cleavage.
Activated caspase-like protein expression.
体内研究
(In Vivo)

β-Amyrin (4 mg/kg, p.o., 每日, 5 天) 改善了 Aβ 诱导的 AD 小鼠模型的物体识别记忆缺陷和海马体神经损伤[1]。
β-Amyrin (20-100 μg/kg, i.p.) 抑制卡拉胶诱导的大鼠足肿胀sup>[2]。
β-Amyrin (20-80 mg/kg, i.g., 每日, 5 天) 通过抑制炎症反应和氧化应激可抑制 BLM 诱导的小鼠肺纤维化[3]。
β-Amyrin 在大鼠体内的药代动力学参数

β-Amyrin standard IV (group 3) β-Amyrin standard oral dose (group 2)
Dose (mg kg−1) 1 3 300 (equivalent of 3mg kg−1 β-amyrin)
V (ml kg−1) 1317
AUC0→24 h (min μg ml−1) 411 10.6 47.3
Cl (ml min−1 kg−1) 2.04
t1/2λZ (h) 10.2 10.3 8.3
MRT0→24 h (h) (h) 8 8.5 8.7
Cmax (ng ml−1) (h) (h) 18.7 75
tmax (h) - 3 (n = 2) or 5 (n = 1) 3 (n = 3) or 5 (n = 1)
F (%) 0.86 3.83

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD-1 mice, 26-28 g, 6 weeks old. 5 μL of Aβ was acutely injected into the left lateral ventricle by hand[1].
Dosage: 4 mg/kg
Administration: p.o., daily, 5 days
Result: Increased number of transitions between the light and dark compartments.
Increased the total exploration time on the light compartment of the apparatus and the time spent in open arms.
Ameliorated the reduction of neurogenesis.
Animal Model: Adult male rats of Sprague–Dawley strain, weighing 150-180 g. Carrageenan induces edema in the hind paw of the rat[2].
Dosage: 20, 50, 100 μg/kg
Administration: i.p.
Result: Significant decreased edema by in a dose dependent manner.
Animal Model: Adult male rats of Sprague–Dawley strain, weighing 150-180 g. Carrageenan induces Use Bleomycin (BLM) (HY-108345), 5mg/kg, one-time intratracheally injection, in 50μL saline per mouse to induce the marine model of pulmonary fibrosis[3].
Dosage: 20, 40, 80 mg/kg
Administration: i.g., daily, 5 days
Result: Promoted the values of SO2 and PO2 and inhibited the value of PCO2.
Significantly improved inflammatory cell infiltration, the thickened alveolar septum and the lesion collapses of the alveoli and formation of flaky lung tissue.
分子量

426.72

Formula

C30H50O
CAS 号
性状

固体

颜色

White to off-white

中文名称

β-香树素；β-香树脂醇
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

Ethanol 中的溶解度 : 5 mg/mL (11.72 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3435 mL 11.7173 mL 23.4346 mL
5 mM 0.4687 mL 2.3435 mL 4.6869 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

请根据您的 实验动物和给药方式 选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 方案 一

    请依序添加每种溶剂： 10% EtOH    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 0.5 mg/mL (1.17 mM); 澄清溶液

    此方案可获得 ≥ 0.5 mg/mL（饱和度未知）的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 5.0 mg/mL 的澄清 EtOH 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水 定容至 1 mL。

    生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
  • 方案 二

    请依序添加每种溶剂： 10% EtOH    90% Corn Oil

    Solubility: ≥ 0.5 mg/mL (1.17 mM); 澄清溶液

    此方案可获得 ≥ 0.5 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。

    以 1 mL 工作液为例，取 100 μL 5.0 mg/mL 的澄清 EtOH 储备液加到 900 μL 玉米油中，混合均匀。

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.95%

COA (302 KB) HNMR (256 KB) RP-HPLC (248 KB)

产品使用指南 (1538 KB)
参考文献

β-Amyrin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.3435 mL 11.7173 mL 23.4346 mL 58.5864 mL
5 mM 0.4687 mL 2.3435 mL 4.6869 mL 11.7173 mL
10 mM 0.2343 mL 1.1717 mL 2.3435 mL 5.8586 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Amyrin559-70-6β-香树素β-香树脂醇Amyloid-βNF-κBβ-amyloid peptideAβAbetaNuclear factor-κBNuclear factor-kappaBAlzheimer’s diseaseSynaptic plasticityanti-inflammatorypulmonary fibrosisantibacterialInhibitorinhibitorinhibit

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