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  3. Beta-Sitosterol (purity>75%)

Beta-Sitosterol (purity>75%)  (Synonyms: β-Sitosterol (purity>75%); 22,23-Dihydrostigmasterol (purity>75%))

目录号: HY-N0171B 纯度: ≥95.0%
COA 产品使用指南

Beta-Sitosterol (purity>75%) 是一种具有口服活性的植物甾醇。Beta-Sitosterol (purity>75%) 可干扰多种细胞信号通路,包括细胞周期,细胞凋亡 (apoptosis) 和细胞增殖。Beta-Sitosterol (purity>75%) 有抗炎、抗氧化和抗肿瘤活性。

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Beta-Sitosterol (purity>75%) Chemical Structure

Beta-Sitosterol (purity>75%) Chemical Structure

CAS No. : 83-46-5

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Beta-Sitosterol (purity>75%) is a phytosterol with oral activity. Beta-Sitosterol (purity>75%) interferes with a variety of cell signaling pathways, including the cell cycle, apoptosis and cell proliferation. Beta-Sitosterol (purity>75%) has anti-inflammatory, antioxidant, and antitumor activities[1][2][3].

体外研究
(In Vitro)

Beta-Sitosterol purity>75% (16 μM, 1, 3, 5 天) 可抑制 MDA-MB-231 人乳腺癌细胞生长和诱导细胞凋亡[1]
Beta-Sitosterol purity>75% (120, 240 μM, 24 h) 对 COLO 320 DM 细胞有明显的剂量依赖性生长抑制作用 (IC50 为 266.2 μM)。通过清除活性氧诱导细胞凋亡,抑制人结肠癌细胞中 β-catenin 和 PCNA 抗原的表达[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: MDA-MB-231
Concentration: 16 μM
Incubation Time: 3 days
Result: No cytotoxicity at 16 μM

Apoptosis Analysis[1]

Cell Line: MDA-MB-231
Concentration: 16 μM
Incubation Time: 5 days
Result: Increased 33% apoptosis when assayed using 1×104 cells and a 6-fold increase in apoptosis when assayed using a smaller number of cells 5×103.

Western Blot Analysis[2]

Cell Line: COLO 320 DM
Concentration: 15, 30, 60, 120 μM
Incubation Time: 24 h
Result: Decreased β-catenin and PCNA expression.
体内研究
(In Vivo)

Beta-Sitosterol purity>75% (10-20 mg/kg, 混悬于 0.1% 的 CMC 中, 口服, 每天一次连续 16 周) 在结肠癌大鼠模型中具有预防癌变作用[2]
Beta-Sitosterol purity>75% (10, 15, 20 mg/kg, 口服, 连续 21 天) 在链脲佐菌素 (HY-13753) 诱导的实验性高血糖大鼠模型中有抗高血糖和抗氧化作用[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Colon cancer rats model [2]
Dosage: 10, 20 mg/kg
Administration: p.o., suspended in 0.1% CMC (1.0 mL)
Result: Reduced the number of aberrant crypt and crypt multiplicity in a dose-dependent manner.
Animal Model: Streptozotocin-induced hyperglycemia rats model[3]
Dosage: 10, 15, 20 mg/kg
Administration: p.o.
Result: Increased insulin levels and decreased HbA1c levels.
Improved pancreatic antioxidant levels and decreased LPO levels.
分子量

414.71

Formula

C29H50O

CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥95.0%

参考文献

Beta-Sitosterol (purity>75%) 相关分类

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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