1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
    Dopamine Receptor
  3. BGC20-761

BGC20-761 

目录号: HY-21995
产品使用指南

BGC20-761 是一种选择性的 5-HT6 和多巴胺受体 (dopamine receptor) 拮抗剂,对人 5-HT6,5-HT2A,D2 受体的 Ki 值分别为 20,69,和 140 nM。BGC20-761 可增强长期记忆。BGC20-761 可用于抗精神病的研究。

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BGC20-761 Chemical Structure

BGC20-761 Chemical Structure

CAS No. : 17375-63-2

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Description

BGC20-761 is a selecvtive 5-HT6 and dopamine receptor antagonist (human receptor Ki values: 5-HT6 (20 nM), 5-HT2A (69 nM), D2 (140 nM). BGC20-761, can enhance long-term memory. BGC20-761 has potential utility as an antipsychotic agent[1].

IC50 & Target[1]

Human 5-HT6 Receptor

20 nM (Ki)

Human 5-HT2A Receptor

69 nM (Ki)

Human D2 Receptor

140 nM (Ki)

In Vitro

BGC20-761 has highly potent and selective 5-HT6 receptor antagonist activity; rat Ki values for other rats receptors: 5-HT2A (470 nM), 5-HT2C (675 nM), D2, D3, D4, DAT and SERT (>10,000 nM)[1].

In Vivo

BGC20-761 enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. BGC20-761 (2.5 mg/kg, 5 mg/kg and 10 mg/kg; i.p.) alone has no effect on social recognition in young rats, however, at doses of 5 mg/kg and 10 mg/kg i.p, BGC20-761 dose-dependently reverses a deficit of social recognition induced by Scopolamine (0.4 mg/kg i.p.)[1].

Animal Model: Forty-two male 8-week-old Longe Evans rats and 12 male four-week-old SpragueeDawley rats[1]
Dosage: 2.5 mg/kg, 5 mg/kg and 10 mg/kg
Administration: Administered (i.p.) immediately after the training session for the social recognition test
Result: Administered alone did not show any difference in social recognition as compared to saline treated control animals. However, 5 mg/kg and 10 mg/kg reversed a Scopolamine induced deficit in social recognition.
Molecular Weight

294.39

Formula

C₁₉H₂₂N₂O

CAS No.

17375-63-2

SMILES

CN(C)CCC1=C(C2=CC=CC=C2)NC3=C1C=C(OC)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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× = ×
C1   V1   C2   V2

Keywords:

BGC20-7615-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT6memoryantipsychoticInhibitorinhibitorinhibit

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产品名称:
BGC20-761
目录号:
HY-21995
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