2. GPCR/G Protein Neuronal Signaling
  3. CGRP Receptor
  4. Cagrilintide acetate

Cagrilintide acetate 是一种非选择性的 AMYR/CTR 激动剂和长效酰化淀粉酶类似物。Cagrilintide acetate 以剂量依赖的方式导致食物摄入减少和体重明显下降。Cagrilintide acetate 可用于肥胖症的研究。

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Cagrilintide acetate

Cagrilintide acetate Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥1500
In-stock
5 mg ￥4500
In-stock
10 mg 现货 询价
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of Cagrilintide acetate:

Cagrilintide acetate 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 3 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cagrilintide acetate is a non-selective AMYR/CTR agonist and long-acting acylated amylase analogue. Cagrilintide acetate causes a reduction in food intake and significant weight loss in a dose-dependent manner. Cagrilintide acetate can be used in obesity studies[1][2][3].

IC50 & Target

AMYR, CTR[1][2][3].
体内研究
(In Vivo)

Cagrilintide acetate (compound 23) (0.1, 1, 3, 10, 30 nmol/kg; s.c.single) reduces food intake in the rat[1].
Cagrilintide acetate (10 nmol/kg; i.v. or s.c.; single) shows good pharmacokinetic parameters[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley male rats (12-week-old; ~400 g)[1]
Dosage: 0.1, 1, 3, 10, 30 nmol/kg
Administration: Subcutaneous injection; single
Result: Reduced food intake in the rat for several days at doses in the range of 1-10 nmol/kg.
Animal Model: Sprague Dawley male rats (12-week-old; ~400 g)[1]
Dosage: 10 nmol/kg
Administration: Intravenous injection or subcutaneous injection; single
Result: Showed good pharmacokinetic parameters with T1/2 of 20, 27 h for i.v. and s.c., respectively.
Clinical Trial
分子量

4409.01 (free base)

Formula

C194H312N54O59S2.xC2H4O2
性状

固体

颜色

White to off-white

Sequence

{Eicosanedioic acid-γ-Glu}-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Glu-Phe-Leu-Arg-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Pro-NH2 (Disulfide bridge:Cys3-Cys8)
Sequence Shortening

{Eicosanedioic acid-γ-Glu}-KCNTATCATQRLAEFLRHSSNNFGPILPPTNVGSNTP-NH2 (Disulfide bridge:Cys3-Cys8)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : 50 mg/mL (超声助溶)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.96%

COA (310 KB) RP-HPLC (252 KB) MS (74 KB)

产品使用指南 (1538 KB)
参考文献

Cagrilintide acetate 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CagrilintideCGRP ReceptorCalcitonin gene-related peptide receptorobesityweight lossfood intakeInhibitorinhibitorinhibit

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产品名称：
Cagrilintide acetate
目录号：
HY-P3462A
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