2. GPCR/G Protein Neuronal Signaling
  3. CGRP Receptor
  4. Cagrilintide

Cagrilintide 是一种在研的新型长效酰化胰淀素类似物，作为非选择性的胰淀素受体 (AMYR) 和 降钙素 G 蛋白偶联受体 (CTR) 激动剂。Cagrilintide 可显着减轻体重并减少食物摄入。Cagrilintide 具有肥胖研究潜力。

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Cagrilintide Chemical Structure

Cagrilintide Chemical Structure

CAS No. : 1415456-99-3

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Cagrilintide 的其他形式现货产品:

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Cagrilintide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cagrilintide is an investigational novel long-acting acylated amylin analogue, acts as nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide induces significant weight loss and reduces food intake. Cagrilintide has the potential for the research of obesity[1][2][3].

体内研究
(In Vivo)

Cagrilintide (compound 23) (0.1, 1, 3, 10, 30 nmol/kg; s.c.) reduces food intake in the rat[2].
Cagrilintide (10 nmol/kg; i.v. or s.c.) shows good pharmacokinetic parameters[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 12 weeks, 400 g Sprague Dawley male rats[2]
Dosage: 0.1, 1, 3, 10, 30 nmol/kg
Administration: S.c.; once for 80 h
Result: Reduced food intake in the rat for several days at doses in the range of 1-10 nmol/kg.
Animal Model: 12 weeks, 400 g Sprague Dawley male rats[2]
Dosage: 10 nmol/kg
Administration: I.v.; s.c.
Result: Showed good pharmacokinetic parameters with T1/2 of 20±2, 27±3 h for i.v. and s.c., respectively.
Clinical Trial
分子量

4409.01

Formula

C194H312N54O59S2
CAS 号
Sequence

{Eicosanedioic acid-γ-Glu}-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Glu-Phe-Leu-Arg-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Pro-NH2 (Disulfide bridge:Cys3-Cys8)
Sequence Shortening

{Eicosanedioic acid-γ-Glu}-KCNTATCATQRLAEFLRHSSNNFGPILPPTNVGSNTP-NH2 (Disulfide bridge:Cys3-Cys8)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cagrilintide 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cagrilintide1415456-99-3CGRP ReceptorCalcitonin gene-related peptide receptorweight lossfood intakeobesityInhibitorinhibitorinhibit

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目录号：
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