2. GPCR/G Protein
  3. G Protein-coupled Receptor Kinase (GRK)
  4. CCG-273463

CCG-273463 是一种有效的、共价的 GRK5 选择性抑制剂，IC50 值为 8.6 nM。CCG-273463 可用于心力衰竭、肥厚型心肌病和癌症的研究。

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CCG-273463 Chemical Structure

CCG-273463 Chemical Structure

CAS No. : 2750413-99-9

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CCG-273463 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CCG-273463 is a potent, selective and covalent GRK5 inhibitor with an IC50 value of 8.6 nM. CCG-273463 can be used in the research of heart failure, hypertrophic cardiomyopathy, and cancer[1].

IC50 & Target

IC50: 8.6 nM (GRK5), 12 μM (GRK2)[1].
体外研究
(In Vitro)

CCG-273463 (0.02-1 μM) potently and highly inhibits GRK5 (IC50: 8.6 nM), with inhibitory rate of 93% (GRK5) and 97% (GRK6) at 1 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CCG-273463 相关抗体:
分子量

521.41

Formula

C26H25BrN4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CCG-273463 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCG-2734632750413-99-9CCG273463CCG 273463G Protein-coupled Receptor Kinase (GRK)Heart failurecancerhypertrophic cardiomyopathyInhibitorinhibitorinhibit

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产品名称：
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目录号：
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