1. GPCR/G Protein
  2. RGS Protein
  3. CCG-50014

CCG-50014 

目录号: HY-13509
产品使用指南

CCG-50014 是 (RGS) protein 4 TDZD 抑制剂 (IC50=30 nM),对 RGS4 的选择性比其他RGS 蛋白高 20 倍。CCG-50014 与 RGS 共价结合,在位于变构调节位点的两个半胱氨酸残基上形成加合物。CCG50014 在小鼠福尔马林试验中减少伤害性反应并增强阿片类药物介导的镇痛作用。

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CCG-50014 Chemical Structure

CCG-50014 Chemical Structure

CAS No. : 883050-24-6

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Description

CCG-50014 is a TDZD inhibitor most potent against G-Protein signaling (RGS) protein 4 (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site[1]. CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test[2].

IC50 & Target[1]

RGS4

30 nM (IC50)

In Vivo

CCG50014 (10, 30, or 100 nM) attenuated the nociceptive responses during the late phase in a dose-dependent manner[2].

Molecular Weight

316.35

Formula

C₁₆H₁₃FN₂O₂S

CAS No.

883050-24-6

SMILES

O=C(N1CC2=CC=C(F)C=C2)N(C3=CC=C(C)C=C3)SC1=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
CCG-50014
目录号:
HY-13509
需求量:

CCG-50014

Cat. No.: HY-13509