1. GPCR/G Protein
  2. RGS Protein
  3. CCG-50014

CCG-50014 

目录号: HY-13509 纯度: >99.0%
产品使用指南

CCG-50014 是 RGS4 抑制剂 (IC50=30 nM),对 RGS4 的选择性比其他 RGS 蛋白高 20 倍。CCG-50014 与 RGS 共价结合,在位于变构调节位点的两个半胱氨酸残基上形成加合物。CCG50014 在小鼠福尔马林试验中减少伤害性反应并增强阿片类药物介导的镇痛作用。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

CCG-50014 Chemical Structure

CCG-50014 Chemical Structure

CAS No. : 883050-24-6

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Price Stock Quantity
1 mg ¥1800 In-stock
5 mg ¥3500 In-stock
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

Description

CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site[1]. CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test[2].

IC50 & Target[1]

RGS4

30 nM (IC50)

RGS8

11 μM (IC50)

RGS16

3.5 μM (IC50)

RGS19

0.12 μM (IC50)

In Vivo

CCG50014 (10, 30, or 100 nM) attenuates the nociceptive responses during the late phase in a dose-dependent manner[2].

Molecular Weight

316.35

Formula

C₁₆H₁₃FN₂O₂S

CAS No.

883050-24-6

SMILES

O=C(N1CC2=CC=C(F)C=C2)N(C3=CC=C(C)C=C3)SC1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CCG-50014CCG50014CCG 50014RGS ProteinRegulators of G-protein SignalingRegulator of G-protein SignalingInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
CCG-50014
目录号:
HY-13509
需求量: