CCP peptide TFA 

CCP peptide TFA is a synthetic cyclic citrullinated peptide (CCP) and used as the substrate for detecting anti-CCP antibodies serologically. CCP peptide TFA functions as a target for autoantibodies with a very high specificity for rheumatoid arthritis (RA)^[1][2].

CCP 肽在抗 CCP ELISA 中用作新的抗原底物，以检测抗瓜氨酸化蛋白抗体 (ACPA)。抗 CCP ELISA 具有极高的特异性 (98%)，具有合理的灵敏度 (68%)。抗 CCP ELISA 对类风湿关节炎 (RA) 的诊断和处理策略非常有用^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2455.49

C₈₉H₁₄₆N₄₁F₃O₃₄S₂

固体

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His-Gln-Cys-His-Gln-Glu-Ser-Thr-{Cit}-Gly-Arg-Ser-Arg-Gly-Arg-Cys-Gly-Arg-Ser-Gly-Ser (Disulfide bridge: Cys3-Cys16)

HQCHQEST-{Cit}-GRSRGRCGRSGS(Disulfide bridge: Cys3-Cys16)

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

• [1]. Puszczewicz M, et al. Role of anti-citrullinated protein antibodies in diagnosis and prognosis of rheumatoid arthritis. Arch Med Sci. 2011 Apr;7(2):189-94.  [Content Brief]

  [2]. Söderlin MK, et al. Antibodies against cyclic citrullinated peptide (CCP) and levels of cartilage oligomeric matrix protein (COMP) in very early arthritis: relation to diagnosis and disease activity. Scand J Rheumatol. 2004;33(3):185-8.  [Content Brief]

  [3]. Schellekens GA, et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum. 2000 Jan;43(1):155-63.  [Content Brief]