2. Cell Cycle/DNA Damage
  3. CDK
  4. Cdc7-IN-20

Cdc7-IN-20 (EP-05) 是一种口服有效的、选择性的 Cdc7 抑制剂， IC50 和 Ki 值分别为 0.93 和 0.11 nM。Cdc7-IN-20 具有抗肿瘤活性。

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Cdc7-IN-20 Chemical Structure

Cdc7-IN-20 Chemical Structure

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Cdc7-IN-20 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cdc7-IN-20 (EP-05) is an orally effective and selective Cdc7 inhibitor with IC50 and Ki values of 0.93 and 0.11 nM, respectively. Cdc7-IN-20 has antitumor activity[1].

体外研究
(In Vitro)

Cdc7-IN-20 (0.5, 1, 2 μM, 24 h) 可抑制 COLO 205 细胞的增殖[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cdc7-IN-20 相关抗体:

Western Blot Analysis[1]

Cell Line: COLO 205
Concentration: 0.5, 1, 2 μM
Incubation Time: 24 h
Result: Inhibited the phosphorylation at Ser53 and Ser40 of MCM2 in a dose-dependent manner.
体内研究
(In Vivo)

Cdc7-IN-20 (2, 4, 8 mg/kg, 口服, 连续 3 天) 在 COLO 205 异种移植小鼠模型中具有抗肿瘤作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: COLO 205 xenograft mice model[1]
Dosage: 2, 4, 8 mg/kg
Administration: p.o. for 3 consecutive days
Result: Inhibit the expression of p-MCM2 protein.
分子量

300.38

Formula

C15H16N4OS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cdc7-IN-20 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cdc7-IN-20CDKCyclin dependent kinaseCdc7InhibitorCOLO 205 cellsAntitumorinhibitorinhibit

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产品名称：
Cdc7-IN-20
目录号：
HY-163374
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