1. Immunology/Inflammation
  2. Interleukin Related
  3. Cendakimab

Cendakimab  (Synonyms: 申达奇单抗; RPC 4046; ABT 308; CC-93538)

目录号: HY-P99496 纯度: 99.96%
COA

Cendakimab (RPC4046; ABT 308; CC-93538) 是一种选择性的、人源化的 IL-13 重组单克隆抗体。Cendakimab 对人野生型和变异体 IL-13 具有高亲和力和效力,并阻断 IL-13 与 IL-13Rα1 和 IL-13Rα2 的结合,通过 ELISA 测定的 IC50 分别为 352 pM 和 631 pM。Cendakimab 识别野生型人 IL-13 和常见的多态变体 R110Q,结合力分别为 52 pM 和 50 pM。Cendakimab 具有潜力用于 IL-13 相关过敏/炎症性疾病,例如哮喘和嗜酸性粒细胞性食管炎。

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Cendakimab Chemical Structure

Cendakimab Chemical Structure

CAS No. : 2151032-62-9

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cendakimab (RPC4046; ABT 308; CC-93538) is a selective, humanized, recombinant monoclonal antibody against the IL-13 molecule. Cendakimab has a high affinity and potency for both human wild-type and variant IL-13 and blocks binding of IL-13 to both IL-13Rα1 and IL-13Rα2 with IC50s of 352 pM and 631 pM by ELISA, respectively. Cendakimab recognizes both wild-type human IL-13 and the common polymorphic variant R110Q, with binding affinities of 52 and 50 pM, respectively. Cendakimab has the potential for IL-13-related allergic/inflammatory diseases (e.g., asthma and eosinophilic esophagitis)[1].

IC50 & Target[1]

IL-13

 

体外研究
(In Vitro)

Cendakimab (RPC4046; ABT 308; CC-93538) 完全中和肺上皮 A-549 细胞中 IL-13 诱导的胸腺和活化调节趋化因子,效力范围为 80 至 513 pM[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

申达奇单抗

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Cendakimab
目录号:
HY-P99496
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