2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. CFL-120

CFL-120  (Synonyms: 4,6-二氯-1H-吲哚-2,3-二酮)

目录号: HY-W041315
COA 产品使用指南

摩尔计算器

CFL-120 是一种有效的 KRasG12C 抑制剂。CFL-120 具有抗增殖作用。CFL-120 显示出抗癌活性。CFL-120具有肺癌研究的潜力。

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CFL-120 Chemical Structure

CFL-120 Chemical Structure

CAS No. : 18711-15-4

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CFL-120 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CFL-120 is a potent KRasG12C inhibitor. CFL-120 shows an antiproliferative effect. CFL-120 shows anticancer activity. CFL-120 has the potential for the research of lung cancer[1].

IC50 & Target[1]

KRAS(G12C)

 

体外研究
(In Vitro)

CFL-120 (72 h) 显示出抗增殖作用，对 H1792, SW1573, MiaPaca2, H358, A549, SW480, PANC-1, LCLC-103H, BxPC3, HCA-7, MRC-5, HUVEC-TERT, CCD-986Sk 细胞的 IC50 值分别为 111.0, 23.6, 13.7, 16.9, 44.4, 14.8, 38.0, 30.0, 13.1, 9.8, 47.9, 24.4, 42.7 µM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CFL-120 相关抗体:
体内研究
(In Vivo)

CFL-120 (5 mg/kg，5 次治疗；15 mg/kg，5 次治疗；30 mg/kg，3 次治疗；i.p.) 减少皮下人肺癌 H1792 (KRasG12C 突变体) 和 LCLC-103H (KRasWT) 小鼠肿瘤模型的生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD/SCID female mice (KRasWT (LCLC-103H) or KRasG12C (H1792) tumors)[1]
Dosage: 5 mg/kg, 5 treatments; 15 mg/kg, 5 treatments; 30 mg/kg, 3 treatments
Administration: I.p.
Result: Reduced tumor growth compared to the control group in KRasG12C mutated model for 35.8%.
分子量

216.02

Formula

C8H3Cl2NO2
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

4,6-二氯-1H-吲哚-2,3-二酮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥98.0%

COA (195 KB) HNMR (121 KB)

产品使用指南 (1538 KB)
参考文献

CFL-120 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CFL-12018711-15-44,6-二氯-1H-吲哚-2,3-二酮CFL120CFL 120RasH1792LCLC-103Hanticancerantiproliferativelung cancerInhibitorinhibitorinhibit

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