2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  3. HSP Apoptosis
  4. Chetomin

Chetomin 作为 Chaetomium globosum 的活性成分，是一种热休克蛋白90/缺氧诱导因子1α (Hsp90/HIF1α) 途径的抑制剂。Chetomin 是一种有效的、无毒的非小细胞肺癌干细胞 (NSCLC CSC) 靶向分子。

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Chetomin Chemical Structure

Chetomin Chemical Structure

CAS No. : 1403-36-7

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1 mg ￥3700
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Chetomin 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chetomin, an active component of Chaetomium globosum, is a heat shock protein 90/hypoxia-inducible factor 1 alpha (Hsp90/HIF1α) pathway inhibitor. Chetomin is a potent, nontoxic non-small cell lung cancer cancer stem cells (NSCLC CSC)-targeting molecule[1].

IC50 & Target[1]

HSP90

 

体外研究
(In Vitro)

Chetomin (0~10 μM；24 小时；H460 和 H1299 细胞) 显示由 Hsp90/HIF1α 活性促进的几种促生存蛋白的表达逐渐降低，包括胰岛素样生长因子 1 (IGF1 R)、表皮生长因子受体 (EGFR)、Src、丝裂原活化蛋白激酶激酶 1/2 (MEK1) /2)、蛋白激酶 B (Akt) 和哺乳动物雷帕霉素靶标 (mTOR) 的激活[1]。
Chetomin (0~10 μM；24 小时；H1299 细胞) 在易感和化疗耐药的 NSCLC 细胞系中引起细胞周期停滞[1]。。
Chetomin (1 μM；3 天；H460 和 H1299 细胞) 预处理消除了它们的球体形成能力。Chetomin 在纳摩尔范围内抑制 NSCLC CSC 的球体形成，并在微摩尔范围内抑制易感和化学耐药的 NSCLC 非 CSC 的增殖。Chetomin (24 h) 降低 H460 和 H1299 单层培养物中的 HIF 反应元件活性。Chetomin (0~10 μM) 特异性抑制 HIF1α N 末端的 Hsp90-HIF1α 结合相互作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Chetomin 相关抗体:

Western Blot Analysis[1]

Cell Line: H460 and H1299 cells
Concentration: 0~10 μM
Incubation Time: 24 hours
Result: Showed progressively lower expression of several survival-promoting proteins promoted by Hsp90/HIF1α activity, including insulin-like growth factor 1 (IGF1 R), epidermal growth factor receptor (EGFR), Src, mitogen-activated protein kinase kinase 1/2 (MEK1/2), activation of protein kinase B (Akt), and mammalian target of rapamycin (mTOR).

Cell Cycle Analysis[1]

Cell Line: H1299 cells
Concentration: 0~10 μM
Incubation Time: 24 hours
Result: Elicited cell cycle arrest in susceptible and chemoresistant NSCLC cell lines.
体内研究
(In Vivo)

Chetomin (0~100 mg/kg；po) 抑制 NSCLC 小鼠模型中的肺肿瘤发生[1]。
Chetomin 显著减少了几种非小细胞肺癌小鼠模型的肿瘤形成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse
Dosage: 0~100 mg/kg
Administration: P.o.
Result: Inhibited lung tumorigenesis in NSCLC mouse models.
分子量

710.87

Formula

C31H30N6O6S4
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

COA (270 KB)

产品使用指南 (1538 KB)
参考文献

Chetomin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chetomin1403-36-7HSPApoptosisHeat shock proteinsChaetomiumglobosumhypoxia-induciblepotentnontoxicnon-smallNSCLCtargetingInhibitorinhibitorinhibit

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