2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage Stem Cell/Wnt Cytoskeleton TGF-beta/Smad
  3. DNA/RNA Synthesis Cytochrome P450 ROCK
  4. Chloroxoquinoline

Chloroxoquinoline  (Synonyms: 7-氯代喹啉-4(1H)-酮)

目录号: HY-W110138
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Chloroxoquinoline 是一种抗癌剂。Chloroxoquinoline 破坏癌细胞的 DNA 模板，诱导 DNA 断裂和细胞死亡，并通过下调 Rho/Rho kinase 信号通路抑制细胞侵袭。Chloroxoquinoline 在荷瘤小鼠模型中增强了Lewis 肺癌细胞和异种移植瘤的放射敏感性，但在大鼠模型中，由于其对 CYP1A 和 CYP3A 产生自诱导作用，经长期暴露后疗效降低。Chloroxoquinoline 具有广谱抗癌活性，如对非小细胞肺癌 (NSCLC)、乳腺癌和胃癌。

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Chloroxoquinoline

Chloroxoquinoline Chemical Structure

CAS No. : 23833-97-8

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Chloroxoquinoline 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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  • 生物活性

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生物活性

Chloroxoquinoline is an anticancer agent. Chloroxoquinoline damages the DNA templates of cancer cells, inducing DNA breaks and cell death, and inhibits cell invasion via down-regulating Rho/Rho kinase signaling pathway. Chloroxoquinoline enhances the radiation sensitivity of Lewis lung cancer cells and xenograft tumors in tumor-bearing mouse models but decreases efficacy after long term exposure in rat models by auto-induction effects on CYP1A and CYP3A. Chloroxoquinoline has a broad-spectrum anticancer activity, such as non-small-cell lung carcinoma (NSCLC), breast cancer and gastric cancer[1].

分子量

179.60

Formula

C9H6ClNO
CAS 号
中文名称

7-氯代喹啉-4(1H)-酮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Chloroxoquinoline 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chloroxoquinoline23833-97-87-氯代喹啉-4(1H)-酮DNA/RNA SynthesisCytochrome P450ROCKCYPsRho-associated protein kinaseRho-associated kinaseRho-kinaseROKDNA templatesRho/Rho kinase signaling pathwayRadiation sensitivityAuto-inductionCYP1ACYP3AAnticancerNSCLCBreast cancerGastric cancerInhibitorinhibitorinhibit

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