2. Inhibitory Antibodies
  3. Cifurtilimab

Cifurtilimab  (Synonyms: SEA-CD40)

目录号: HY-P99603 纯度: 95.00%
COA

摩尔计算器

Cifurtilimab (SEA-CD40) 是一种人源的抗 CD40 IgG1 单克隆抗体。Cifurtilimab 具有抗癌活性。

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Cifurtilimab Chemical Structure

Cifurtilimab Chemical Structure

CAS No. : 1629760-27-5

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规格 价格 是否有货 数量
1 mg ￥4000
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Cifurtilimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cifurtilimab (SEA-CD40) is an agonistic nonfucosylated, human IgG1 monoclonal antibody directed against CD40. Cifurtilimab shows antitumor activities[1][2].

IC50 & Target

CD40[1]
体外研究
(In Vitro)

Cifurtilimab 增强了 FcγRIIIa 结合 (比亲本 IgG1 抗体大 10 倍)，驱动效应因子功能的增强，导致比具有沉默或选择性 FcγR 结合的抗体更强的免疫刺激活性[1]。
暴露于 Cifurtilimab 会导致明显的反应特征，包括 APCs、CD8+ 和 CD4+ T 细胞和 NK 细胞的激活，以及 CD40+ B 细胞的靶向衰竭[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cifurtilimab 相关抗体:
体内研究
(In Vivo)

在临床前小鼠模型中，Cifurtilimab 与化疗药物联合使用可增强抗肿瘤活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cifurtilimab1629760-27-5SEA-CD40OthersantitumorAPCsCD8+CD4+Inhibitorinhibitorinhibit

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