2. Apoptosis
  3. Caspase
  4. Cimiside E

Cimiside E  (Synonyms: 25-Anhydrocimigenol xyloside)

目录号: HY-N10018
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摩尔计算器

Cimiside E (25-Anhydrocimigenol xyloside) 是一种三萜木糖苷，对胃癌细胞有凋亡作用，IC50 为 14.58 μM。Cimiside E 诱导细胞周期阻滞，并通过诱导 caspase 级联的外部和内在途径介导细胞凋亡。

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Cimiside E Chemical Structure

Cimiside E Chemical Structure

CAS No. : 154822-57-8

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Cimiside E 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cimiside E (25-Anhydrocimigenol xyloside) is a triterpene xyloside, Cimiside E possesses apoptotic action on gastric cancer cells, with an IC50 value of 14.58 μM. Cimiside E induces cell cycle arrest at G2/M phase, and mediates apoptosis through the induction of the caspase cascade for both the extrinsic and intrinsic pathways[1][2].

IC50 & Target[1]

Caspase 3

 

体外研究
(In Vitro)

Cimiside E (30-90 μM; 24 h) 阻滞细胞周期，诱导 ASG 细胞凋亡[1]。
Cimiside E (30-90 μM; 12-48 h) 对 AGS 细胞有较强的细胞毒性，并表现出抗增殖活性[1]。
Cimiside E (15-60 μM; 6-24 h) 诱导 ASG细胞中 DNA 片段化，(30-60 μM; 1-6 h) 并在 3 h 时激活 FasL 的表达，在 1 h 激活 Fas[1]。
Cimiside E (30-90 μM; 3-24 h) 介导 caspase 级联，增加 Bax/Bcl-2 比值，降低突变型 p53 和 procaspase 3 蛋白水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cimiside E 相关抗体:

Western Blot Analysis[1]

Cell Line: Cimiside E. AGS cells
Concentration: 30 μM, 60 μM, and 90 μM
Incubation Time: 3 h, 6 h, 12 h, and 24 h
Result: Increased the ratio of Bax/Bcl-2 expression from 60 μM.
Decreased mutant type (mt) p53 levle from 12 h at 30 µM.
Suppressed the protein level of procaspase 3 in a dose-dependent manner from 30 μM.

Cell Proliferation Assay[1]

Cell Line: Cimiside E. AGS cells
Concentration: 30 μM, 60 μM, and 90 μM
Incubation Time: 12 h, 24 h, and 48 h
Result: Inhibited ASG cells proliferation with IC50s of 28.7, 14.6 and 8.1 µM, respectively, for 30 μM, 60 μM, and 90 μM treatment.

Cell Cycle Analysis[1]

Cell Line: Cimiside E. AGS cells
Concentration: 30 μM, 60 μM, and 90 μM
Incubation Time: 3 h, 6 h, and 24 h
Result: Induced cell cycle arrest at S phase in a low concentration (30 μM), but arrested cell cycle at G2/M phase in higher concentration (60 μM and 90 μM).
分子量

602.80

Formula

C35H54O8
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cimiside E 相关分类

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Keywords:

Cimiside E154822-57-825-Anhydrocimigenol xylosideCaspaseInhibitorinhibitorinhibit

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