1. Others Anti-infection
  2. Isotope-Labeled Compounds Parasite
  3. Closantel-13C6

Closantel-13C6  (Synonyms: 氯氰碘柳胺-13C6)

目录号: HY-17596S
产品使用指南

Closantel-13C613C6 标记的 Closantel。Closantel 是有效的抗寄生虫活性的卤化水杨酰苯胺。Closantel 是一种有效且高度特异性的盘尾丝虫几丁质酶 (OvCHT1) 抑制剂,IC50 为 1.6 μM,Ki 为 468 nM。Closantel 抑制了食蟹曲霉 L3 至 L4 的蜕皮。

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Closantel-<sup>13</sup>C<sub>6</sub> Chemical Structure

Closantel-13C6 Chemical Structure

CAS No. : 1325559-20-3

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Closantel-13C6 is the 13C6 labeled Closantel. Closantel is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel inhibits the O. volvulus L3 to L4 molt of developing.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

669.03

Formula

C1613C6H14Cl2I2N2O2

CAS 号
中文名称

氯氰碘柳胺-13C6;氯生太尔-13C6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Closantel-13C6
目录号:
HY-17596S
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