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  2. Parasite
  3. Conoidin A

Conoidin A 

目录号: HY-116090 纯度: 98.03%

Conoidin A 是刚地弓形虫过氧化物酶 II (TgPrxII) 的细胞通透性抑制剂,有杀线虫的特性。Conoidin A 共价结合 TgPrxII 的过氧化物催化位点 Cys47,不可逆地抑制其过氧化物活性,IC50 为 23 µM。Conoidin A 也抑制哺乳动物 PrxI 和 PrxII (但不抑制 PrxIII) 的氧化。Conoidin A 具有抗氧化、神经保护作用,并且可用于缺血性心脏病的研究。

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Conoidin A Chemical Structure

Conoidin A Chemical Structure

CAS No. : 18080-67-6

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥550 In-stock
25 mg ¥500 In-stock
100 mg ¥1000 In-stock
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500 mg   询价  

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Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. Conoidin A covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 µM. Conoidin A also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII)[1][2]. Conoidin A has antioxidant, neuroprotective effects and can be used for the research of ischaemic heart disease[3].

IC50 & Target

IC50: 23 µM (T. gondii enzyme peroxiredoxin II (TgPrxII))[1]

(In Vitro)

Peroxiredoxins are a widely conserved family of enzymes that function in antioxidant defense and signal transduction. And the changes in PrxII expression are associated with a variety of human diseases, including cancer[1].
Conoidin A binds to the peroxidatic cysteine of TgPrxII, inhibiting its enzymatic activity in vitro. Conoidin A also shown to alkylate or crosslink catalytic cysteines of wild type AcePrx-1 in Ancylostoma ceylanicum and human PrxII and PrxIV with similar efficiency. But it is ineffective to mitochondrial hPrxIII[2].
Conoidin A (5 µM) can inhibit the glucose oxidase-mediated hyperoxidation of mammalian peroxiredoxin I and II[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(In Vivo)

Conoidin A (intraperitoneal injection; 5 mg/kg; for three successive days before MI/R injury) blocks the effect of Luteolin (HY-N0162) on the ST‐segment elevation. Furthermore, an increase in the infarct size presented of the MI/R group can be reduced by Luteolin. But pre‐treatment with conoidin A abolishs the effect of Luteolin. Pre‐treatment with conoidin A also prevents Luteolin-reduced activities of CK‐MB, AST and LDH in vivo[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat myocardial I/R model[3]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; 5 mg/kg; for three successive days before MI/R injury
Result: Significantly reversed the antioxidative effect of Luteolin.
Impaired the protective effects of luteolin.





Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
In Vitro: 

DMSO : 14.29 mg/mL (41.06 mM; Need ultrasonic)

浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8736 mL 14.3682 mL 28.7365 mL
5 mM 0.5747 mL 2.8736 mL 5.7473 mL
10 mM 0.2874 mL 1.4368 mL 2.8736 mL

储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.43 mg/mL (4.11 mM); Clear solution

    此方案可获得 ≥ 1.43 mg/mL (4.11 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 14.3 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液
*以上所有助溶剂都可在 MCE 网站选购。
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Conoidin A