1. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  2. HSP Apoptosis
  3. CPUY201112

CPUY201112 是一种有效的热休克蛋白 Hsp90 抑制剂,其 Kd 值为27 nM。CPUY201112 可诱导 p53 介导的 MCF-7 细胞凋亡,使细胞周期停滞,可用于癌症研究。

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CPUY201112 Chemical Structure

CPUY201112 Chemical Structure

CAS No. : 1860793-58-3

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  • 参考文献


CPUY201112 is a potent heat shock protein Hsp90 inhibitor with Kd of 27 nM. CPUY201112 induces p53-mediated apoptosis in MCF-7 cells, resulting in cell cycle arrest, which can be used in cancer research[1].

(In Vitro)

CPUY201112 (0-9 μM, 7 days) 以剂量依赖的方式降低多种癌细胞系的活力, 如 HCT116 结肠细胞、HepG2 肝细胞癌和其他癌细胞[1]
CPUY201112 (0-2 μM, 24 h) 可以剂量依赖性诱导细胞凋亡[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: HCT116, HepG2, MCF-7, A549
Concentration: 0-9 μM
Incubation Time: 7 days
Result: Inhibited MCF-7, A549, HCT116 and HepG2 cells with the IC50 values of 0.624, 0.543, 0.763 and 0.342 μM, respectively.

Apoptosis Analysis[1]

Cell Line: MCF-7 and HCT116 cells
Concentration: 0-2 μM
Incubation Time: 24 h
Result: Induced cell cycle arrest in G2/M phase and induced apoptosis in more than 35% of MCF-7 cells.
Induced p53-mediated apoptosis in HCT116 cells.
(In Vivo)

CPUY201112 (5-40 mg/kg, i.p., daily, 3 weeks) 在 MCF-7 肿瘤异种移植模型中抑制了肿瘤生长[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nude mice with MCF-7 cell[1]
Dosage: 5 mg/kg, 20 mg/kg and 40 mg/kg
Administration: i.p., daily, 3 weeks
Result: Reduced tumor volume by 11.92%, 26.58% and 39.63%, respectively, when using 5 mg/kg, 20 mg/kg and 40 mg/kg.
Significantly induced the expression of Hsp70 and reduced the expression of Akt at 40 mg/kg.





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