2. NF-κB Apoptosis Immunology/Inflammation Stem Cell/Wnt MAPK/ERK Pathway Cell Cycle/DNA Damage Epigenetics
  3. NF-κB TNF Receptor COX ERK p38 MAPK Sirtuin
  4. Cudraflavone B

Cudraflavone B 是一种异戊二烯化类黄酮，具有抗炎和抗癌特性。Cudraflavone B 也是 COX-1 和 COX-2 的双重抑制剂。Cudraflavone B 阻断巨噬细胞中 核因子 κB (NF-κB) 从细胞质到细胞核的易位。由此，Cudraflavone B 也抑制肿瘤坏死因子 α (TNFα) 的基因表达和分泌。Cudraflavone B 还触发线粒体凋亡通路，激活 NF-κB、MAPK p38 和 ERK，并诱导 SIRT1 的表达。由此，Cudraflavone B 抑制人口腔鳞状细胞癌细胞的生长。

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Cudraflavone B Chemical Structure

Cudraflavone B Chemical Structure

CAS No. : 19275-49-1

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Cudraflavone B 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

查看 ERK 亚型特异性产品:

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ERK ERK1 ERK2 ERK5 ERK8

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 Sirtuin 亚型特异性产品:

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Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells[1][2].

IC50 & Target[1][2]

NF-κB

 

COX-2

 

COX-1

 

TNFRSF1A

 

p38 MAP kinase

 

ERK

 

SIRT1

 

分子量

420.45

Formula

C25H24O6
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cudraflavone B 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cudraflavone B19275-49-1NF-κBTNF ReceptorCOXERKp38 MAPKSirtuinNuclear factor-κBNuclear factor-kappaBTumor Necrosis Factor ReceptorTNFRCyclooxygenaseExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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