2. Apoptosis Autophagy
  3. Apoptosis Autophagy
  4. Curcumin 5-8

Curcumin 5-8  (Synonyms: CUR5-8)

目录号: HY-148598
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摩尔计算器

Curcumin 5-8 (CUR5-8) 是一种天然活性姜黄素 (CUR) 类似物。Curcumin 5-8 抑制脂滴形成。Curcumin 5-8 促进细胞自噬 (autophagy) 并抑制细胞凋亡 (Apoptosis)。Curcumin 5-8 改善胰岛素抵抗和胰岛素敏感性。

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Curcumin 5-8 Chemical Structure

Curcumin 5-8 Chemical Structure

CAS No. : 890984-26-6

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Curcumin 5-8 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. Curcumin 5-8 inhibits lipid droplet formation. Curcumin 5-8 increases autophagy and inhibits Apoptosis. Curcumin 5-8 improves insulin resistance and insulin sensitivity[1].

体外研究
(In Vitro)

Curcumin 5-8 (20 µM; 24 h) 降低 AML12 细胞中 PA (palmitic acid (HY-N0830)) 诱导的 SREBP1 表达水平并增加 Bcl2/BAX 表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Curcumin 5-8 相关抗体:

Western Blot Analysis[1]

Cell Line: AML12 cells
Concentration: 20 µM
Incubation Time: 24 h
Result: Significantly decreased PA-induced SREBP1 expression levels, increased Bcl2/BAX expression.
体内研究
(In Vivo)

Curcumin 5-8 (100 mg/kg; diet; daily for 13 weeks) 改善 HFD (高脂肪饮食) 诱导的肥胖小鼠的胰岛素抵抗和肝脂肪变性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old males, 20 g, C57BL/6 mice[1]
Dosage: 100 mg/kg
Administration: Diet; daily for 13 weeks
Result: Significantly suppressed the increases in the insulin level and HOMA-IR.
分子量

339.39

Formula

C20H21NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Curcumin 5-8 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Curcumin 5-8890984-26-6CUR5-8ApoptosisAutophagyautophagyapoptosislipid dropletSREBP1AML12 cellsinsulin resistanceorally activeInhibitorinhibitorinhibit

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