2. Anti-infection Apoptosis
  3. Antibiotic Bacterial Apoptosis Bcl-2 Family Caspase
  4. Cytochalasin H

Cytochalasin H 是一种天然产物，可以从真菌 Phomopsis sp 中分离得到。Cytochalasin H 抑制细胞生长并诱导细胞凋亡 (apoptosis)。Cytochalasin H 具有抗血管生成活性。Cytochalasin H 是一种抗生素，具有抗菌活性。

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Cytochalasin H Chemical Structure

Cytochalasin H Chemical Structure

CAS No. : 53760-19-3

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1 mg ￥2749
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Cytochalasin H 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cytochalasin H is a nature product that could be isolated from fungus Phomopsis sp. Cytochalasin H inhibits cell growth and induces apoptosis. Cytochalasin H has anti-angiogenic activity. Cytochalasin H is an antibiotic and has antibacterial activity[1][2][3].

体外研究
(In Vitro)

Cytochalasin H (24-72 h) 抑制 A549 细胞的增殖，IC50 值为 159.5 µM[1]。
Cytochalasin H (0-50 µM; 48 h) 在 A549 细胞中诱导细胞凋亡，使细胞周期停滞在 G2/M 期，并影响细胞凋亡相关蛋白的表达[1]。
Cytochalasin H (1-512 μg/mL) 对 MDR 肠道致病菌、革兰氏阳性菌和金黄色葡萄球菌具有抗菌活性[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cytochalasin H 相关抗体:

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 0, 6.25, 12.5, 25 and 50 µM
Incubation Time: 48 h
Result: Induced apoptosis in a dose-dependent manner in the A549 cells.

Cell Cycle Analysis[1]

Cell Line: A549 cells
Concentration: 0, 6.25, 12.5, 25 and 50 µM
Incubation Time: 48 h
Result: Arrested cell cycle at the G2/M phase and sub-G1 peaks.

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 0, 6.25, 12.5, 25 and 50 µM
Incubation Time: 48 h
Result: Increased the protein expression levels of Bax, P53 and cleaved caspase-3 and decreased the protein expression levels of Bcl-xL, Bcl-2 and full-length caspase-3.
体内研究
(In Vivo)

Cytochalasin H (2.5 mg/kg; i.p.) 可以延迟 Balb/cnu/nu 小鼠中 A549 异种移植肿瘤的生长[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: male Balb/cnu/nu mice with A549 xenograft[2]
Dosage: 2.5 mg/kg
Administration: intraperitoneal injection; 3 injections/week,for 80 days
Result: Attenuated tumor growth in vivo.
分子量

493.63

Formula

C30H39NO5
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cytochalasin H 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cytochalasin H53760-19-3AntibioticBacterialApoptosisBcl-2 FamilyCaspasenature productfungusPhomopsisanti-angiogenicbacterialA549 cellsInhibitorinhibitorinhibit

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