2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Aldose Reductase Reactive Oxygen Species
  4. Danshenol A

Danshenol A  (Synonyms: 丹参醇A)

目录号: HY-122917
产品使用指南

摩尔计算器

Danshenol A 是一种松香类二萜类化合物，是一种醛糖还原酶 (AR) 抑制剂，IC50 为 0.1 μM。Danshenol A 可以通过直接清除 ROS 来保护内皮细胞免受氧化应激。Danshenol A 具有抗炎和抗肿瘤特性，可用于动脉粥样硬化研究。

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Danshenol A Chemical Structure

Danshenol A Chemical Structure

CAS No. : 189308-08-5

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Danshenol A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Danshenol A, an abietane-type diterpenoid, is an aldose reductase (AR) inhibitor with an IC50 of 0.1 μM. Danshenol A can protect endothelial cells from oxidative stress by directly scavenging ROS. Danshenol A has anti-inflammatory and antitumor properties. Danshenol A can be used for atherosclerosis research[1][2][3][4].

IC50 & Target

IC50: 0.1 μM (Aldose reductase)[3]
体外研究
(In Vitro)

Danshenol A (10 nM; pretreatment for 1 h) 单独处理显示对 ICAM-1 在 mRNA 和蛋白质水平的表达没有影响。Danshenol A 显着逆转 TNF-α 诱导的 ICAM-1 表达和随后的单核细胞粘附，以及升高的活性氧 (ROS) 生成和 NOX4 表达[1].
Danshenol A 通过 NOX4 依赖性 IKKβ/NF-κB 通路抑制 TNF-α 诱导的 ICAM-1 表达和随后的单核细胞与内皮细胞的粘附[1]。
Danshenol A (1, 3, and 10 μM; pretreated for 35 min) 恢复血管紧张素 II 诱导的心肌细胞凋亡。此外，Danshenol A 抑制心肌细胞线粒体氧化还原信号通路[2]。
Danshenol A 抑制 K562 (IC50 = 0.53 μg/mL)、T-24 (IC50 = 7.94 μg/mL)、QGY (IC50 = 4.65 μg/mL) 和 Me180 (IC50 = 6.89 μg/mL) 细胞系的活性[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Danshenol A 相关抗体:

Western Blot Analysis[1]

Cell Line: HUVEC cells
Concentration: 10 nM
Incubation Time: Pretreatment for 1 h
Result: Showed no effect on the ICAM-1 expression at both mRNA and protein levels.
体内研究
(In Vivo)

Danshenol A (0.3-3mg/kg；口服；每天一次；持续 12 周) 改善 SHR 大鼠的血压、心脏损伤和心肌胶原体积，并改善心功能。Danshenol A 修复线粒体结构/功能，减轻心肌氧化应激[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Forty male spontaneously hypertensive rats (SHR) and eight male Wistar-Kyoto (WKY) rats at the age of 16 weeks[2]
Dosage: 0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration: Orally administration; daily; for 12 weeks
Result: Ameliorated blood pressure, cardiac injury, and myocardial collagen volume and improved cardiac function.
分子量

336.38

Formula

C21H20O4
CAS 号
中文名称

丹参醇A
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Danshenol A 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Danshenol A189308-08-5丹参醇AAldose ReductaseReactive Oxygen SpeciesAldose reductaseabietane-type diterpenoidROSanti-inflammatoryantitumoratherosclerosis,Inhibitorinhibitorinhibit

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