2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. DBCO-PEG2-Val-Cit-PAB-MMAE

DBCO-PEG2-Val-Cit-PAB-MMAE 

目录号: HY-172287 纯度: 99.27%
COA 产品使用指南 技术支持

DBCO-PEG2-Val-Cit-PAB-MMAE 是一种 ADC 连接子，具有 DBCO 基团、Val-Cit 二肽、PAB 基序和 MMAE 弹头。DBCO 基团是一种点击化学手柄，可与叠氮基团发生反应，而 Val-Cit 是一种蛋白酶可裂解的二肽，可通过消除机制将 MMAE 弹头释放到细胞中。

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DBCO-PEG2-Val-Cit-PAB-MMAE

DBCO-PEG2-Val-Cit-PAB-MMAE Chemical Structure

CAS No. : 2845934-59-8

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规格 价格 是否有货 数量
5 mg ￥2750
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10 mg ￥4500
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Customer Review

DBCO-PEG2-Val-Cit-PAB-MMAE 相关抗体

Top Publications Citing Use of Products

查看 ADC Linker 亚型特异性产品:

查看所有亚型
Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

  • 生物活性

  • 纯度 & 产品资料

生物活性

DBCO-PEG2-Val-Cit-PAB-MMAE is an ADC linker featuring a DBCO group, a Val-Cit dipeptide, a PAB motif, and an MMAE warhead. The DBCO group is a click chemistry handle which readily reacts with azide groups, while the Val-Cit is a protease-cleavable dipeptide which releases the MMAE warhead into cells via an elimination mechanism.

体外研究
(In Vitro)

ADC 由一个抗体和 ADC 细胞毒素通过 ADC 连接子连接而成。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DBCO-PEG2-Val-Cit-PAB-MMAE 相关抗体:
分子量

1569.92

Formula

C84H120N12O17
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

纯度 & 产品资料

DBCO-PEG2-Val-Cit-PAB-MMAE 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DBCO-PEG2-Val-Cit-PAB-MMAE2845934-59-8ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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