Dextran sulfate sodium salt (MW 450000-550000)  (Synonyms: DSS (MW 450000-550000); DXS (MW 450000-550000))

Dextran sulfate sodium salt (DSS) (MW 450000-550000) is a polymer of dehydrated glucose with a molecular weight of approximately 450000-550000. Dextran sulfate sodium salt with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 450000-550000) inhibits replication of HIV-1 and influenza A virus. Dextran sulfate sodium salt (MW 450000-550000) can be formulated as nanoparticles and shows antibacterial activity. Dextran sulfate sodium salt (MW 450000-550000) can be used for functional material preparation^{[1][2][3][4][5][6]}.

抗菌活性：
Dextran sulfate sodium salt (MW 500000) 纳米颗粒可采用凝胶化技术配制。配制的 DSS 纳米颗粒 (MIC：150-250 μg/mL) 对革兰氏阳性菌和革兰氏阴性菌表现出广泛的活性，例如大肠杆菌、化脓性链球菌、枯草芽孢杆菌、肺炎克雷伯菌、铜绿假单胞菌、金黄色葡萄球菌和假单胞菌^[1]。

抗病毒活性：
Dextran sulfate sodium salt (MW 500000) 抑制 MT-4 细胞中 HIV-1 的复制 (IC₅₀：10.9 μg/mL)^[5]。
Dextran sulfate sodium salt (MW 500000) (30 μg/mL) 抑制 MT-4 细胞中 HIV-1 的复制^[6]。

功能材料制备：
Dextran sulfate sodium salt (MW 500000) 可掺入自组装 PEI-DNA 复合物 (一种非病毒基因传递聚合物) 中减少细胞毒性^[3]。
Dextran sulfate sodium salt (MW 500000) 具有血液相容性并与血液成分相互作用。DSS 可以共价结合到纤维素膜上，用于研究改性膜的血小板粘附能力^[4]。
其他：
Dextran sulfate sodium salt (MW 450000-550000) (3% w/v) 可用于从人和大鼠血液中分离中性粒细胞^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

450000-550000

9011-18-1

固体

White to off-white

硫酸葡聚糖钠盐 (MW 450000-550000)

Room temperature in continental US; may vary elsewhere.

• [1]. Madkhali OA, et al. E. Formulation and evaluation of injectable dextran sulfate sodium nanoparticles as a potent antibacterial agent. Sci Rep. 2021 May 10;11(1):9914.  [Content Brief]

  [2]. Aaltonen N, et al. High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections - Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils. Biol Proced Online. 2020 Mar 15;22:6.  [Content Brief]

  [3]. Tiyaboonchai W, et al. Formulation and characterization of DNA-polyethylenimine-dextran sulfate nanoparticles. Eur J Pharm Sci. 2003 Jul;19(4):191-202.  [Content Brief]

  [4]. Erdtmann M, et al. Photochemical immobilization of heparin, dermatan sulphate, dextran sulphate and endothelial cell surface heparan sulphate onto cellulose membranes for the preparation of athrombogenic and antithrombogenic polymers. Biomaterials. 1994 Oct;15(13):1043-8.  [Content Brief]

  [5]. Baba M, et al. Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro. Proc Natl Acad Sci U S A. 1988 Aug;85(16):6132-6.  [Content Brief]

  [6]. Lüscher-Mattli M, et al. Dextran sulfate inhibits the fusion of influenza virus with model membranes, and suppresses influenza virus replication in vivo. Antiviral Res. 1990 Jul;14(1):39-50.  [Content Brief]