2. Metabolic Enzyme/Protease JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. Dihydrofolate reductase (DHFR) EGFR
  4. DHFR-IN-4

DHFR-IN-4 是一种有效的二氢叶酸还原酶 (DHFR) 抑制剂IC50 为 123 nM。DHFR-IN-4 对 EGFR 和 HER2 也具有抑制活性，IC50 分别为 246 nM 和 357 nM。DHFR-IN-4 对癌细胞具有显著的广谱细胞毒性活性。

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DHFR-IN-4 Chemical Structure

DHFR-IN-4 Chemical Structure

CAS No. : 2820126-49-4

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DHFR-IN-4 相关抗体

Top Publications Citing Use of Products

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with an IC50 value of 123 nM. DHFR-IN-4 also has inhibitory activity against EGFR and HER2 with IC50s of 246 nM and 357 nM, respectively. DHFR-IN-4 has remarkable broad spectrum cytotoxic potency against cancer cells[1].

IC50 & Target

IC50: 123 nM (DHFR), 246 nM (EGFR), 357 nM (HER2)[1]
体外研究
(In Vitro)

DHFR-IN-4 (compound 42) (0-100 μM; 72 h) shows remarkable broad spectrum cytotoxic potency against HepG2, MCF-7, HCT-116, PC3 and HeLa[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DHFR-IN-4 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HepG2, MCF-7, HCT-116, PC3 and HeLa
Concentration: 0-100 μM
Incubation Time: 72 h
Result: Exhibited antiproliferative activity against HepG2, MCF-7, HCT-116, PC3 and HeLa with IC50s of 9.67±0.7 μM, 8.46±0.7 μM, 13.24±0.9 μM, 11.17±1.0 μM and 6.90±0.5 μM.
分子量

371.46

Formula

C18H21N5O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DHFR-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHFR-IN-42820126-49-4Dihydrofolate reductase (DHFR)EGFREpidermal growth factor receptorErbB-1HER1dihydrofolate reductaseDHFRanticancerHepG2MCF-7HCT-116PC3HeLaInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-151159
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