2. Immunology/Inflammation
  3. STING
  4. diABZI STING agonist-1 (tautomerism)

diABZI STING agonist-1 (tautomerism) 

目录号: HY-112921 纯度: 99.91%
COA 产品使用指南 技术支持

diABZI STING agonist-1 tautomerism 是 diABZI STING agonist-1 (HY-112921A) 的互变异构体。diABZI STING agonist-1 tautomerism 是一个选择性的干扰素基因刺激受体 (STING) 的激动剂，其在人和小鼠中的 EC50 值分别为 130 nM 和 186 nM。。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

diABZI STING agonist-1 (tautomerism)

diABZI STING agonist-1 (tautomerism) Chemical Structure

CAS No. : 2138498-18-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥1591
In-stock
5 mg ￥3500
In-stock
10 mg ￥5900
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Other Forms of diABZI STING agonist-1 (tautomerism):

diABZI STING agonist-1 (tautomerism) 相关抗体

Top Publications Citing Use of Products
WB
IF

    diABZI STING agonist-1 (tautomerism) purchased from MCE. Usage Cited in: Cell Res. 2022 Dec;32(12):1086-1104.  [Abstract]

    Western blot analysis of EVPs isolated from HeLa, HCT116, and B16F10 cells treated with or without 10 µM STING agonist-1 (diABZI), 1 µM cGAMP, or 50 µg/mL DMXAA for 48 h.

    diABZI STING agonist-1 (tautomerism) purchased from MCE. Usage Cited in: Cell Res. 2022 Dec;32(12):1086-1104.  [Abstract]

    Immunofluorescence analysis of STING (green) and Flag-RAB22AQ64L (red) in stable Flag-RAB22AQ64L NCI-H1975 cells treated with or without 1 µM STING agonist-1 (diABZI) for 1 h.

    diABZI STING agonist-1 (tautomerism) purchased from MCE. Usage Cited in: Cell Res. 2022 Dec;32(12):1086-1104.  [Abstract]

    Western blot analysis of the WCL of the indicated stable 4T1 cells at the indicated time points after treatment with 10 µM STING agonist-1 (diABZI).

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    diABZI STING agonist-1 tautomerism is a tautomerism of diABZI STING agonist-1 (HY-112921A). diABZI STING agonist-1 tautomerism is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively[1].

    IC50 & Target

    EC50: 130 nM (human STNG in PBMCs) [1].
    体外研究
    (In Vitro)

    diABZI STING agonist-1 tautomerism 是一种选择性干扰素基因刺激剂 (STING) 受体激动剂，对人和小鼠的 EC50 分别为 130 nM 和 186 nM。在 1 μM 浓度下，diABZI STING agonist-1 (compound 3) 对 350 多种受试激酶表现出高选择性[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    diABZI STING agonist-1 (tautomerism) 相关抗体:
    体内研究
    (In Vivo)

    diABZI STING agonist-1 (皮下注射；2.5 mg/kg) tautomerism 在体内诱导 STING 依赖性的 I 型干扰素和促炎细胞因子激活[1]。
    diABZI STING agonist-1 (静脉注射；3 mg/kg) tautomerism 表现出全身暴露，半衰期为 1.4 小时，达到的全身浓度大于半最大有效浓度(EC50) 为小鼠 STING (200 ng/mL)[1]。
    diABZI STING agonist-1 (静脉注射；1.5 mg/kg；43 天) tautomerism 可显著抑制肿瘤生长，并显著提高生存率，在第 43 天的研究结束时，10 只小鼠中有 8 只仍无肿瘤[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    849.94

    Formula

    C42H51N13O7
    CAS 号
    性状

    固体

    颜色

    White to light yellow

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    纯度 & 产品资料
    参考文献

    diABZI STING agonist-1 (tautomerism) 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    diABZI STING agonist-1 (tautomerism)2138498-18-5STINGStimulator of Interferon GenesTMEM173MITAERISMPYSInhibitorinhibitorinhibit

    您最近查看的产品:

    Your information is safe with us. * Required Fields.

       产品名称：

    		  

    * 需求量：

    * 客户姓名：

    		 

    * Email：

    * 电话：

    		 

    * 公司或机构名称：

       留言给我们：

    Bulk Inquiry

    Inquiry Information

    产品名称：
    diABZI STING agonist-1 (tautomerism)
    目录号：
    HY-112921
    需求量：

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

       产品名称：

    		  

    * Lot #：

    * 客户姓名：

    		 

    * Email：

       电话：

    		 

    * 部门：

    * 公司或机构名称：

    		 

       留言给我们：

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.

    嗨！很高兴为您提供帮助！

    尊敬的 MCE 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z