2. 一站式药筛
  3. 化合物库
  4. 生物活性化合物库系列
  5. 疾病相关化合物库
  6. 神经退行性疾病化合物库
神经退行性疾病化合物库 - Neurodegenerative Disease-related Compound Library

Cat. No.: HY-L086

神经退行性疾病是神经元结构或功能逐渐丧失甚至死亡而导致功能障碍的一类疾病，包括肌萎缩侧索硬化症、帕金森病、阿尔茨海默病、亨廷顿氏病以及脊髓性肌萎缩症等。目前，这类疾病病因尚不明确也无法治愈，严重威胁着人类健康与日常生活。由于对神经退行性疾病的疾病机理知之甚少，对靶标的发现及确认充满挑战，加之新药研发过程复杂且成功率低，因此，确认新的靶点，并开发能够缓解神经退行性疾病的新药是当务之急。

MCE 收录了 2228 种具有抗神经退行性活性的化合物及靶向神经退行性疾病主要靶点的化合物。MCE 神经退行性疾病相关化合物库是研究神经退行性疾病发病机制及开发新型药物的有用工具。

我们将在明确您的产品用途后，向符合资质的客户通过定制合成服务的方式提供 MCE 神经退行性疾病化合物库，我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中，2194 个产品以 10 mM 浓度提供，34 个产品以 2 mM 浓度提供。

溶液包装中，我们对于溶液状态稳定且溶解度不低于 10 mM 的产品，提供 10 mM 溶液；对于溶液状态稳定且溶解度介于 2~10 mM 的产品，我们提供 2 mM 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

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MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 产品资料
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 2228 compounds for high throughput screening (HTS) and high content screening (HCS).

•   Targets include Amyloid-β, Dopamine Receptor, COMT, LRRK2, 5-HT Receptor, Monoamine Oxidase, nAChR, Histamine Receptor, etc.

•   A useful tool for exploring the mechanism of neurodegenerative diseases and looking for new treatments.

•   Bioactivity and safety confirmed by clinical trials or preclinical research. Some have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   Detailed compound information with structure, IC50, and brief introduction.

•   High purity and quality validated by NMR and LC/MS.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 2228 neurodegenerative disease-related compounds supplied as pre-dissolved Solutions or Solid
Solution: 2194 compounds supplied in 10 mM solution, 34 compounds supplied in 2 mM solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice

化合物库组成

Composition

mAChR (102)

iGluR (100)

GSK-3 (68)

mGluR (52)

nAChR (40)

CDK (24)

ERK (21)

LRRK2 (20)

Akt (18)

Src (17)

PKC (14)

PARP (12)

VEGFR (11)

COX (10)

EGFR (10)

JNK (10)

Notch (10)

PI3K (10)

COMT (8)

DYRK (8)

JAK (8)

PKA (8)

Wnt (7)

FLT3 (6)

HDAC (6)

MMP (6)

PPAR (6)

STAT (6)

AMPK (4)

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  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式（固体或溶液）
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联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称：
    Neurodegenerative Disease-related Compound Library
    目录号：
    HY-L086
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