2. Apoptosis NF-κB Metabolic Enzyme/Protease Epigenetics Immunology/Inflammation Neuronal Signaling Membrane Transporter/Ion Channel
  3. Ferroptosis Reactive Oxygen Species (ROS) Epigenetic Reader Domain COX Calcium Channel Cholinesterase (ChE)
  4. Diplacone

Diplacone  (Synonyms: Nymphaeol A; Propolin C)

目录号: HY-N16129
产品使用指南 技术支持

Diplacone (DP) 是一种香叶基黄烷酮。Diplacone 可从泡桐 (Paulownia tomentosa) 的未成熟果实中分离得到。Diplacone 具有抗炎、抗自由基、细胞保护、抗菌和抗癌活性。Diplacone 通过增加线粒体 Ca2+ 内流、ROS 生成和线粒体通透性转换来诱导铁死亡(ferroptosis) 介导的细胞死亡。Diplacone 显著抑制 AChE 和 BChE 的活性，对 hAChE 和 BChE 的 IC50 分别为 7.2 μM 和 1.4 μM。 Diplacone 可用于炎症性肠病 (IBD) 等慢性炎症性疾病，肺癌等癌症和阿尔茨海默病研究。

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Diplacone

Diplacone Chemical Structure

CAS No. : 73676-38-7

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Diplacone 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

查看 Calcium Channel 亚型特异性产品:

查看所有亚型
N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Diplacone (DP) is a geranylated flavanone. Diplacone can be isolated from the unripe fruits of Paulownia tomentosa. Diplacone has anti-inflammatory, antiradical, cytoprotective, antibacterial and anticancer activities. Diplacone induces ferroptosis-mediated cell death by increasing mitochondrial Ca2+ Influx, ROS production and mitochondrial permeability transition. Diplacone significantly inhibits AChE and BChE activity with IC50s of 7.2  μM and 1.4 μM for hAChE and BChE, respectively. Diplacone can be used for chronic inflammatory diseases like inflammatory bowel diseases (IBD), cancers like lung cancer and Alzheimer’s disease research[1][2][3].

IC50 & Target[1][2][3]

COX-2

 

hAChE

7.2 μM (IC50)

BChE

1.4 μM (IC50)

分子量

424.49

Formula

C25H28O6
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Diplacone 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diplacone73676-38-7Nymphaeol A Propolin CFerroptosisReactive Oxygen Species (ROS)Epigenetic Reader DomainCOXCalcium ChannelCholinesterase (ChE)CyclooxygenaseCa2+ channelsCa channelsGeranylated flavanoneA549 cellsAnti-inflammatoryAntiradicalCytoprotectiveAntibacterialAnticancerAChEBChEIBDLung cancerAlzheimer’s diseaseInhibitorinhibitorinhibit

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