2. 疾病领域
  3. 血液和心血管疾病
  4. 心血管疾病

Cardiovascular Disease  (心血管疾病)

心血管疾病是指一组影响心脏和血管的疾病，包括冠心病和血管异常。它与KCNQ1等遗传因素有关，KCNQ1在心脏电活动中发挥作用，并涉及与胰岛素样生长因子调节和间充质干细胞分化相关的通路。富马酸二甲酯和地氟烷等药物已被证明与其治疗或病理生理学有关。主要受影响的组织包括心脏和内皮细胞，临床表现包括稳态、代谢和肌肉功能紊乱。

Cardiovascular Disease refers to a group of conditions affecting the heart and blood vessels, including coronary heart disease and vascular abnormalities. It is associated with genetic factors such as KCNQ1, which plays a role in cardiac electrical activity, and involves pathways related to insulin-like growth factor regulation and mesenchymal stem cell differentiation. Drugs like Dimethyl fumarate and Desflurane have been implicated in its management or pathophysiology. Key affected tissues include the heart and endothelial cells, with clinical manifestations involving disturbances in homeostasis, metabolism, and muscle function.

 

Cardiovascular Disease (1):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0385
    Gomisin J

    戈米辛J

    		66280-25-9 99.97%
    Gomisin J 是一五味子来源的木脂素，可靶向 eNOS、AMPK (LKB1、CaMKIIβ)、fetuin-A、NF-κB、Nrf2/HO-1 等多个靶点，且能通过血脑屏障。Gomisin J 通过激活 eNOS 增加 NO 生物利用度、激活 AMPK 通路调节脂代谢、抑制 fetuin-A 和 NF-κB 发挥抗炎作用、激活 Nrf2/HO-1 增强抗氧化能力等机制。Gomisin J 具有抗高血压、调节肝脂代谢、减轻脑缺血再灌注损伤等活性，可用于高血压、非酒精性脂肪肝、脑缺血再灌注损伤等研究。
    Gomisin J
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