2. PI3K/Akt/mTOR
  3. mTOR PI3K Akt
  4. Doxepin

Doxepin  (Synonyms: 多塞平)

目录号: HY-B0725A
产品使用指南

摩尔计算器

Doxepin 是作为三环类抗抑郁药，可抑制血清素和去甲肾上腺素的再摄取。Doxepin 对特应性皮炎、慢性荨麻疹有研究作用，能改善认知过程，保护中枢神经系统。Doxepin 也被认为是抗氧化应激的保护因子。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Doxepin Chemical Structure

Doxepin Chemical Structure

CAS No. : 1668-19-5

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Doxepin 的其他形式现货产品:

Customer Review

Other Forms of Doxepin:

Doxepin 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant. Doxepin has therapeutic effects in atopic dermatitis，chronic urticarial，can improve cognitive processes， protect central nervous system. Doxepin has also been proposed as a protective factor against oxidative stress[1][2][3].

体外研究
(In Vitro)

The protective effect of doxepin is associated with the enhancement of PSD-95 and synapsin 1 expression via PI3K/AKT/mTOR signaling pathway[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Doxepin 相关抗体:

Western Blot Analysis[4]

Cell Line: SH-SY5Y human neuroblastoma cell line
Concentration: 10 ng/mL
Incubation Time: 2 h
Result: Improved the protein expre-ssion levels of PSD-95, synapsin 1 and p-AKT in SH-SY5Y cells, and decreased the protein expression level of p-mTOR in SH-SY5Y cells.
体内研究
(In Vivo)

Doxepin (intraperitoneal injection of 1 mg/kg and 5 mg/kg doxepin once a day for 21 days) can protect against the Aβ1-42-induced memory impairment in rats[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD male rats[4]
Dosage: 1, 5mg/kg
Administration: Doxepin (intraperitoneal injection of 1 mg/kg and 5 mg/kg doxepin once a day for 21 days)
Result: Improved the protein expression levels of PSD-95 and synapsin 1 in hippocampus and tem-poral lobe, and decreased the protein expression level of p-AKT in hippocampus and temporal lobe after treatment of 1 mg/kg of doxepin.
Clinical Trial
分子量

279.38

Formula

C19H21NO
CAS 号
中文名称

多塞平
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Doxepin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Doxepin1668-19-5多塞平mTORPI3KAktMammalian target of RapamycinPhosphoinositide 3-kinasePKBProtein kinase BantidepressantAponalQuitaxonSinequanInhibitorinhibitorinhibit

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