1. GPCR/G Protein Neuronal Signaling
  2. Adrenergic Receptor
  3. Droxidopa

Droxidopa  (Synonyms: 屈昔多巴; L-DOPS; DOPS; SM5688)

目录号: HY-13458 纯度: 95.00%
COA 产品使用指南

Droxidopa (L-DOPS; SM5688) 是一种有效的口服活性去甲肾上腺素前体。Droxidopa 可增加站立血压,改善体位性低血压症状并提高站立能力。Droxidopa 具有研究神经源性体位性低血压(nOH)和替代性多动症 (注意缺陷多动障碍) 的潜力。

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Droxidopa Chemical Structure

Droxidopa Chemical Structure

CAS No. : 23651-95-8

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100 mg ¥3440
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Droxidopa (L-DOPS; SM5688) is a potent, orally active norepinephrine precursor. Droxidopa increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability. Droxidopa has the potential for the research of neurogenic orthostatic hypotension (nOH) and alternative ADHD (attention deficit hyperactivity disorder)[1][2][3][4].

体内研究
(In Vivo)

Droxidopa (200 mg/kg;i.p.) alters dopamine neuron and prefrontal cortex activity and improves attention-deficit/hyperactivity disorder-like behaviors in rats[2]. Droxidopa (10, 20 mg/kg; i.p.) significantly increases the paw withdrawal latency and inhibits mechanical hypersensitivity to thermal stimulation in 6-OHDA-lesioned rats at the 5th week after surgery[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 250-380g male Sprague-Dawley rats[2]
Dosage: 200 mg/kg (10 mg/kg, i.p. benserazide was given to the animals at 20 or 30 min prior to L-DOPS injection)
Administration: I.p.
Result: Significantly decreased hyperactivity of BZ-pretreated SHR/NCrl at 30 (P < 0.01) and 40 min (P < 0.05) post-injection, improved inattention-like behavior of SHR/NCrl, and ameliorated impulsive-like behavior of SHR/NCrl and Wistar rats.
Clinical Trial
分子量

213.19

Formula

C9H11NO5

CAS 号
性状

固体

颜色

White to off-white

中文名称

屈西多巴杂质1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 95.00%

参考文献
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Droxidopa
目录号:
HY-13458
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