2. Anti-infection
  3. Fungal
  4. Efungumab

Efungumab 是一种具有抗真菌 (fungal) 活性的单克隆抗体。Efungumab 与 HSP90 结合，阻止真菌生存所需的构象变化。Efungumab 可用于侵袭性念珠菌感染 (IC) 的研究。

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Efungumab Chemical Structure

Efungumab Chemical Structure

CAS No. : 762260-74-2

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Efungumab 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Efungumab is a monoclonal antibody with antifungal activity. Efungumab binds to HSP 90, preventing a conformational change needed for fungal viability. Efungumab can be used for research on invasive candidiasis (IC)[1].

体内研究
(In Vivo)

Efungumab (2 mg/kg， i.p.， 每日一次， 持续三天) 在 CD1 小鼠念珠菌 c. albicans 传播性模型中显著降低器官上菌株的平均集落个数，并增加肝活检阴性结果[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD1 mice models of disseminated c. albicans disease[2]
Dosage: 2 mg/kg, daily for 3 days
Administration: Intraperitoneal injection (i.p.)
Result: Decreased mean organ colony counts and increased negative liver biopsies for many of the isolates.
Clinical Trial
CAS 号
储存方式

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纯度 & 产品资料
参考文献

Efungumab 相关分类

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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Efungumab762260-74-2Fungalmonoclonal antibodyantifungalinvasive candidiasis (IC)Inhibitorinhibitorinhibit

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