1. GPCR/G Protein
  2. Apelin Receptor (APJ) Arrestin
  3. ELA-21 (human)

ELA-21 (human) 是一种 apelin 受体激动剂,pKi 为 8.52。ELA-21 (human) 在亚纳摩尔效价下,完全抑制 Forskolin 诱导的 cAMP 产生,并刺激 β-arrestin 募集。ELA-21 (human) 也是 G 蛋白依赖性和非依赖性途径的激动剂。

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Custom Peptide Synthesis

ELA-21 (human) Chemical Structure

ELA-21 (human) Chemical Structure

CAS No. : 2245073-05-4

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ELA-21 (human) is an apelin receptor agonist with a pKi of 8.52. ELA-21 (human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment with subnanomolar potencies. ELA-21 (human) is an agonist in G-protein-dependent and -independent pathways[1].

分子量

2587.14

Formula

C112H184N40O25S3

CAS 号
性状

固体

颜色

White to off-white

Sequence

Leu-Arg-Lys-His-Asn-Cys-Leu-Gln-Arg-Arg-Cys-Met-Pro-Leu-His-Ser-Arg-Val-Pro-Phe-Pro (Disulfide bridge: Cys6-Cys11)

Sequence Shortening

LRKHNCLQRRCMPLHSRVPFP (Disulfide bridge: Cys6-Cys11)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

纯度 & 产品资料
参考文献

ELA-21 (human) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
ELA-21 (human)
目录号:
HY-P2249
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