2. Anti-infection Apoptosis
  3. Bacterial Apoptosis
  4. Epimedokoreanin B

Epimedokoreanin B  (Synonyms: 朝藿素B)

目录号: HY-N3831
产品使用指南

摩尔计算器

Epimedokoreanin B 是一种天然黄酮类化合物，具有抗癌、抗炎和抗菌作用。Epimedokoreanin B 通过内质网应激介导的伴随自噬体积聚的细胞凋亡 (apoptosis) 抑制肺癌细胞的生长。Epimedokoreanin B 是一种抗牙周炎剂，可抑制牙龈蛋白酶和牙龈卟啉单胞菌的生长和生物膜形成。

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Epimedokoreanin B Chemical Structure

Epimedokoreanin B Chemical Structure

CAS No. : 161068-53-7

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1 mg ￥2400
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Epimedokoreanin B 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Epimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and Porphyromonas gingivalis growth and biofilm formation[1][2][3].

体外研究
(In Vitro)

Epimedokoreanin B (compound6; 3.13-25 μM; 48 hours) 对肺癌细胞 A549、Calu1 和 H1299 的增殖显示出显着的抑制作用。Epimedokoreanin B 对人支气管上皮细胞 BEAS-2B 无毒性[1]。
Epimedokoreanin B 处理抑制 A549 和 NCI-H292 细胞中伴随细胞质空泡形成的细胞增殖和迁移。Epimedokoreanin B 处理的细胞中观察到自噬体聚集并伴有自噬通量阻断，这与内质网应激的发生相符[2]。
Epimedokoreanin B（5 μM；24 小时）抑制 CD163 表达和 IL-10 的产生，这是已知的 M2 标记，表明 Epimedokoreanin B 抑制人单核细胞衍生巨噬细胞 (HMDM) 中的 M2 极化。Epimedokoreanin B 抑制 HMDMs 中的 STAT3 激活[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Epimedokoreanin B 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: A549, Calu1 and H1299 cells
Concentration: 3.13 μM, 6.25 μM, 12.5 μM and 25.0 μM
Incubation Time: 48 hours
Result: Showed significate inhibitory effect on proliferation against lung cancer cell A549, Calu1 and H1299.

Western Blot Analysis[4]

Cell Line: Human monocyte-derived macrophages (HMDMs)
Concentration: 5 μM
Incubation Time: 24 hours
Result: Significantly suppressed IL-10-induced JAK1/STAT3 activation.and H1299.
体内研究
(In Vivo)

Epimedokoreanin B（20 mg/kg；口服；每周三次；持续 17 天）抑制 LM8 荷瘤鼠模型中的肿瘤生长[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C3H mice (8-10 weeks old) injected with LM8 cells[4]
Dosage: 20 mg/kg
Administration: Oral administration; thrice a week; for 17 days
Result: Inhibited tumor growth.
分子量

422.47

Formula

C25H26O6
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

朝藿素B
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

Epimedokoreanin B 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Epimedokoreanin B161068-53-7朝藿素BBacterialApoptosisflavonoidanticanceranti-inflammatory and antibacterial effectsanti-periodontitis agentSTAT3lung cancer cellsInhibitorinhibitorinhibit

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