2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. ERCC1-XPF-IN-1

ERCC1-XPF-IN-1 是一种有效且具有高亲和力的 ERCC1-XPF 抑制剂，IC50 为 0.49 μM。ERCC1-XPF-IN-1 通过抑制 CPDs 的去除、以及环磷酰胺对结直肠癌细胞的毒性，增强了 UV 辐射的细胞毒性作用，抑制 DNA 修复。

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ERCC1-XPF-IN-1 Chemical Structure

ERCC1-XPF-IN-1 Chemical Structure

CAS No. : 2411584-25-1

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ERCC1-XPF-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ERCC1-XPF-IN-1 is a potent and high-affinity ERCC1-XPF inhibitor with IC50 value of 0.49 μM. ERCC1-XPF-IN-1 has the capacity to potentiate the cytotoxicity effect of UV radiation and inhibiting DAN repair, by the inhibition of removal of CPDs, and cyclophosphamide toxicity to colorectal cancer cells[1].

IC50 & Target

IC50: 0.49 μM (ERCC1-XPF)[1]
体外研究
(In Vitro)

ERCC1-XPF-IN-1 (compound B7) (2 μM; 0-24 hours) significantly inhibits the removal of CPDs in UV-irradiated HCT-116 cells[1].
ERCC1-XPF-IN-1 (5-20 μM; 72 hours) exhibits approximately 95% of the HCT116 cells survived at 5 μM[1].
ERCC1-XPF-IN-1 (2 and 4 μM; 72 hours) significantly sensitizes HCT 116 cells to cyclophosphamide[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ERCC1-XPF-IN-1 相关抗体:

Cell Cytotoxicity Assay

Cell Line: HCT-116[1]
Concentration: 5, 10, 15 and 20 μM
Incubation Time: 72 hours
Result: Exhibited approximately 95% of the HCT116 cells survived at 5 μM.
体内研究
(In Vivo)

ERCC1-XPF-IN-1 has a moderate rate of metabolism in human liver microsomes, with log D value of 2.01 at pH 7.4 and an efflux ratio ≥ 43.39[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

506.04

Formula

C28H32ClN5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ERCC1-XPF-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ERCC1-XPF-IN-12411584-25-1DNA/RNA SynthesisERCC1-XPFDNA DamageUVCell cytotoxicityHCT-116CyclophosphamideCPDsInhibitorinhibitorinhibit

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