1. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Autophagy
  2. EGFR Autophagy
  3. Erlotinib-13C6 hydrochloride

Erlotinib-13C6 hydrochloride  (Synonyms: CP-358774-13C6 hydrochloride; NSC 718781-13C6 hydrochloride; OSI-774-13C6 hydrochloride)

目录号: HY-12008S1
产品使用指南

Erlotinib-13C6 (hydrochloride) 是 13C 标记的 Erlotinib Hydrochloride。 Erlotinib Hydrochloride (CP-358774 Hydrochloride) 抑制 EGFR 激酶的 IC50 为 2 nM。Erlotinib-13C6 (hydrochloride) 是一种点击化学试剂。它含有 Alkyne 基团,可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

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Erlotinib-<sup>13</sup>C<sub>6</sub> hydrochloride Chemical Structure

Erlotinib-13C6 hydrochloride Chemical Structure

CAS No. : 1210610-07-3

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Erlotinib-13C6 (hydrochloride) is the 13C labeled Erlotinib Hydrochloride[1]. Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM[2]. Erlotinib-13C6 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

435.85

Formula

C1613C6H24ClN3O4

CAS 号
中文名称

盐酸埃罗替尼-13C6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Erlotinib-13C6 hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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