1. Metabolic Enzyme/Protease NF-κB Membrane Transporter/Ion Channel Neuronal Signaling
  2. Gutathione S-transferase NF-κB Calcium Channel
  3. Ethacrynic acid D5

Ethacrynic acid D5 是 Ethacrynic acid 的氘代物。Ethacrynic acid 是一种利尿剂。Ethacrynic acid 是谷胱甘肽 S-转移酶 (GSTs) 的抑制剂。Ethacrynic acid 是 NF-κB 信号传导途径的有效抑制剂,并且还调节白三烯的形成。Ethacrynic acid 还抑制 L 型电压依赖性和储存操作的钙通道,从而导致气道平滑肌细胞松弛。Ethacrynic acid 具有抗炎特性,可减轻类维生素A诱导的小鼠耳部水肿。

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Ethacrynic acid D5 Chemical Structure

Ethacrynic acid D5 Chemical Structure

CAS No. : 1330052-59-9

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生物活性

Ethacrynic acid D5 is a deuterium labeled Ethacrynic acid. Ethacrynic acid is a diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice[1][2][3][4].

IC50 & Target

Glutathione S-transferases (GSTs)[1]; NF-κB-signaling pathway[2]; L-type voltage-dependent and store-operated calcium channel[3]

分子量

308.17

Formula

C13H7D5Cl2O4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Ethacrynic acid D5
目录号:
HY-108538
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